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Tuesday, December 07, 2010

CONTRAVE (BUPROPION + NALTREXONE)

FDA Advisory Panel Recommends the FDA approve the diet drug Contrave (bupropion + naltrexone)

A Food and Drug Administration advisory panel voted 13-7 to recommend approval for the diet drug Contrave, which is a combination of Wellbutrin (bupropion) and naltrexone according to an article on TheStreet.com. Read the entire article | Email this article
Posted by Admin2 on Tue, Dec 07, 2010 3:16 pm | [0] comments

Friday, August 20, 2010

CONTRAVE (BUPROPION + NALTREXONE)

Most common side effects from Contrave: Nausea 34%, headache 24%, constipation 24%, dizziness 15%

The most common side effects in people given Contrave (bupropion SR (Wellbutrin) plus naltrexone SR) were:
  • Nausea reported by 34% of patients vs 11% in the placebo group

  • Headache reported by 24% of patients vs 18%

  • Constipation reported by 24% of patients vs 5%

  • Dizziness reported by 15% of patients vs 5%

  • Insomnia reported by 9% of patients vs 6%

  • Dry mouth reported by 8% of patients vs 3%

  • Anxiety reported by 5% of patients vs 4%

  • Tremor reported by 6% of patients vs 1%

  • Abdominal pain reported by 6% of patients vs 2%

  • Ringing in the ears (tinnitus) reported by 5% of patients vs 1%
Read the entire article | Email this article
Posted by Admin2 on Fri, Aug 20, 2010 9:21 am | [0] comments

Thursday, August 19, 2010

CONTRAVE (BUPROPION + NALTREXONE)

Contrave plus diet, exercise and behavior mod causes weight loss of 9.3% vs 5.1%

People given Contrave (bupropion SR (Wellbutrin) plus naltrexone SR) combined with an intensive program of diet, exercise, and behavior modification therapy lost an average of 9.3% of body weight compared to 5.1% for those given a placebo according to a new one-year (56-week) study.

The average weight loss in the drug group was 21 lbs, reducing their body weight from 224 lbs to 203 lbs, a 9.3% weight loss, compared to an average weight loss in the placebo group was 11 lbs, reducing their body weight from 220 lbs to 209 lbs, a 5.1% weight loss.

Note: This weight loss is the average for patients who either completed the entire one-year study, and the last weight measured if the patient dropped out later in the study. For example, if a patient had lost 8% after 8 months, and then dropped out of the study, a weight loss of 8% would be recorded as the amount of weight lost even though the patient did not complete the entire study. Read the entire article | Email this article
Posted by Admin2 on Thu, Aug 19, 2010 10:18 am | [0] comments

CONTRAVE (NALTREXONE + BUPROPION)

Contrave plus diet, exercise causes weight loss of 11.5% vs 7.3% in those completing one year study

Among participants who completed the entire one-year (56 week) study, those given Contrave (bupropion SR (Wellbutrin) plus naltrexone SR) combined with an intensive program of diet, exercise, and behavior modification therapy to lost an average of 11.5% of body weight compared to 7.3% for those given a placebo.

The average weight loss in the drug group was 26 lbs, reducing their body weight from 224 lbs to 198 lbs, a 11.5% weight loss, compared an average weight loss in the placebo group was 16 lbs, reducing their body weight from 220 lbs to 204 lbs, a 7.3% weight loss.

Note: In order to calculate weight loss in pounds, I made the assumption that the average body weight of those who completed the study was the same as the entire group. Read the entire article | Email this article
Posted by Admin2 on Thu, Aug 19, 2010 10:10 am | [0] comments

Monday, October 22, 2007

CONTRAVE

Contrave dose of 400 mg Wellbutrin plus 32 mg naltrexone causes maximum weight loss

Contrave, a drug combination of Wellbutrin (bupropion) and naltrexone, causes the most weight loss with doses of 400 mg of Wellbutrin (bupropion) plus 32 mg of immediate-release naltrexone according to a press release from Orexigen Therapeutics, the company developing this drug combination. Read the entire article | Email this article
Posted by Admin2 on Mon, Oct 22, 2007 6:35 am | [4] comments

CONTRAVE

Contrave (400 mg Wellbutrin plus 32 mg naltrexone) causes weight loss of 10.7% after 11 months

Contrave, a combination of Wellbutrin (bupropion) and naltrexone, at the optimum doses of 400 mg of Wellbutrin (bupropion) plus 32 mg of immediate-release naltrexone, caused an average weight loss of 10.7 percent after eleven months according to a press release from Orexigen Therapeutics, the company developing this drug combination. Read the entire article | Email this article
Posted by Admin2 on Mon, Oct 22, 2007 6:24 am | [0] comments

CONTRAVE

Contrave (400 mg Wellbutrin + 32 mg naltrexone): 7.9% dropouts; with 48 mg naltrexone, 18% dropouts

Drop out rates for the first six months for those given Contrave, with various doses of Wellbutrin (bupropion) and naltrexone, were 7.9 percent for those given 32 mg of naltrexone plus 400 mg of Wellbutrin (bupropion) compared to 18 percent for those given 48 mg of naltrexone plus 400 mg of Wellbutrin (bupropion) according to a press release from Orexigen Therapeutics, the company developing this drug combination. Read the entire article | Email this article
Posted by Admin2 on Mon, Oct 22, 2007 6:18 am | [0] comments

CONTRAVE

Contrave (400 mg Wellbutrin plus 32 mg naltrexone): Nausea most common side effect

Nausea was the most common adverse effect of Contrave, the drug combination of 32 mg of naltrexone plus 400 mg of Wellbutrin (bupropion) according to a press release from Orexigen Therapeutics, the company developing this drug combination. Other side effects include headache, dizziness and insomnia. "There was no indication of meaningful adverse effects of Contrave therapy on vital signs including blood pressure and pulse, ECG intervals, laboratory evaluations or... depression," the press release noted.

Read the entire article | Email this article
Posted by Admin2 on Mon, Oct 22, 2007 6:15 am | [0] comments

Friday, March 30, 2007

CONTRAVE

Contrave (300 mg Wellbutrin plus 50 mg naltrexone) causes weight loss of 6.6 percent in six months

Among patients who completed the six month study, those given Contrave, a drug combination of Wellbutrin (bupropion) and naltrexone, lost an average of 6.8 percent of their body weight in six months compared to 3.8 percent for those given Wellbutrin (bupropion) alone, 2.2 percent for for those given naltrexone alone, and 1 percent for patients given a placebo according a paper by Frank Greenway and George Bray (2007). (The placebo group was discontinued after four months.) Read the entire article | Email this article
Posted by Admin2 on Fri, Mar 30, 2007 2:36 am | [0] comments

CONTRAVE

Contrave with varying doses causes 7-8% weight loss in six months, 8-9% in nine months

Among patients who finished the study, those given Contrave, with higher than 300 mg doses of Wellbutrin (bupropion) and one of three different doses of naltrexone -- I assume less than 50 mg used in the previous study in order to try and reduce nausea -- lost an average of 7 percent to 7.6 percent after six months compared to 1.1 percent for those given a placebo. After nine months, the average weight loss for those still in the study was 8 percent to 9.3 percent. Read the entire article | Email this article
Posted by Admin2 on Fri, Mar 30, 2007 2:12 am | [2] comments
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