Diabetic patients using subcutaneous injections of Symlin (pramlintide), as well as diet, exercise and lifestyle changes, lost an average of 7.9 pounds in six months versus 4.6 pounds in those given injections of a placebo, a increase of 3.3 lbs -- a small increase in weight loss -- according to a new study from the makers of Symlin (pramlintide). Read the entire article | Email this article

Diabetic patients who took phentermine in addition to giving themselves subcutaneous injections of Symlin (pramlintide), as well as diet, exercise and lifestyle changes, lost an average of 23.9 lbs in six months versus 7.9 lbs with Symlin (pramlintide) injections alone versus 4.6 lbs in those given injections of a placebo, a difference of 19.3 lbs according to a new study from the makers of Symlin (pramlintide). Read the entire article | Email this article

Diabetic patients who took Meridia (sibutramine) in addition to giving themselves subcutaneous injections of Symlin (pramlintide), as well as diet, exercise and lifestyle changes, lost an average of 23.9 lbs in six months versus 4.6 lbs in those given injections of a placebo, a difference of 19.3 lbs according to a new study from the makers of Symlin (pramlintide). Read the entire article | Email this article

People injecting 120 mcg of the diabetes drug Symlin (pramlintide) three times per day in addition to being given dietary counseling lost an average of 7.9 pounds in six months compared to 4.6 pounds for those given a placebo (injections plus pills) according to a study by Amy Halseth, MD from Amylin Pharmaceuticals, San Diego, California presented at the European Association for the Study of Diabetes 2008. Read the entire article | Email this article

People injecting 120 mcg of the diabetes drug Symlin (pramlintide) three times per day plus dietary counseling plus 37.5 mg of phentermine in the morning lost an average of 24.9 pounds in six months compared to 4.6 pounds for those given a placebo (injections plus pills) according to a study by Amy Halseth, MD from Amylin Pharmaceuticals, San Diego, California presented at the European Association for the Study of Diabetes 2008. Read the entire article | Email this article

A dose of 120 mcg of Symlin (pramlintide) injected three times per day was as effective at causing weight loss as doses two and three times this large (240 mcg and 360 mcg) injected three times per day according to a new study.

"All three three-times-daily doses [of Symlin (pramlintide)] were effective over [one year], with 240 mcg and 360 mcg [three times per day] providing little additional benefit over 120 mcg [three times per day]," noted the authors of a new study testing Symlin (pramlintide) for weight loss. Read the entire article | Email this article

When Symlin (pramlintide) was injected twice a day instead of three times per day, 360 mcg caused more weight loss than 240 mcg or 120 mcg according to a new study.

When given twice a day, injections were given before breakfast and dinner. The lunch dose was skipped.

"In contrast to three-times-daily dosing regimens, a clear dose-response relationship was evident among twice-daily regimens, whereby 120 [mcg twice a day] was suboptimal and 360 [mcg twice a day] elicited weight loss of a magnitude similar to the three-times-daily regimens," the authors of a new study noted.

"Thus, at higher doses, twice-daily dosing appears to be a feasible pramlintide regimen for weight loss."

Comment: In other words, 120 mcg three times per day causes as much weight loss as higher doses, however, if a patient only prefers to give themselves injections twice a day instead of three times per day, then giving 360 mcg twice a day also works. Read the entire article | Email this article

Symlin (pramlintide) at a dose of 120 mcg three times per day caused diabetics to lose an average of 7 pounds more than those given a placebo in four months which was 3.1 percent of body weight, and 13.4 pounds more than placebo after one year which was 5.6 percent of body weight according to a new study. Read the entire article | Email this article

Symlin (pramlintide) at a dose of 360 mcg twice a day caused diabetics to lose an average of 7.3 pounds more than those given a placebo in four months which was 3.1 percent of body weight, and 15.8 pounds more than placebo after one year which was 6.8 percent of body weight according to a new study.
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Symlin (pramlintide) caused nausea in 9 percent of patients given 240 mcg three times per day and 29 percent of patients given 360 mcg three times per day versus 2 percent of those given a placebo. Read the entire article | Email this article

Obese people given two experimental drugs, pramlintide plus leptin, caused an average weight loss of 12.7 percent versus 8.4 percent in those given only pramlintide, and 8.2 percent in those only given leptin according to a study by Amylin Pharmaceuticals in San Diego, California, the company who is developing the drugs. The drugs were injected subcutaneously ( under the skin ) three times a day. The company suggests that pramlintide may help to restore leptin sensitivity which is diminished in obese people. Read the entire article | Email this article