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QUOTE OF THE DAY
QUICKLINKS AND VIEW OPITONS
Friday, February 13, 2015
Prof. Peter Gotzsche, MD
12 serious heart problems deleted from diabetes drug study of rosiglitazone (Avandia), Dr. Gotzsche
Prof. Peter Gotzsche, MD notes that the RECORD trial of the diabetes drug rosiglitazone (Avandia) was terribly manipulated by GlaxoSmithKline.
An article published in the New York Times on July 9, 2010 titled, “Caustic Government Report Deals Blow to Diabetes Drug” revealed that Dr. Thomas Marciniak, a reviewer at the US Food and Drug Administration (FDA), found a dozen instances in which patients taking Rosiglitazone (Avandia) suffered serious heart problems that were not counted in the study’s tally of adverse events.
The article also notes that “It [ Rosiglitazone (Avandia) ] has been shown to increase the risks of bone fractures and to cause swelling that can lead to heart failure and eye problems.”
The article also notes that “Dr. Jerome P. Kassirer, a former editor of The New England Journal, said the Record trial raised the question “whether the entire system is corrupt.””Read the entire article | Email this article
Sunday, December 14, 2014
Is metformin a life-extending drug? Metformin LOWERS risk of death in Type 2 diabetics vs controls
Type 2 diabetics taking metformin were LESS likely to die during a 2.8-year follow-up than non-diabetic controls leading the authors of the study to suggest that metformin might have a life-extending effect even in non-diabetics.
“Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls,” the authors of the paper noted.
“This supports the position of metformin as first-line therapy and implies that metformin may confer benefit in non-diabetes.”
To say this another way, the authors of the study are suggesting that metformin might be life-extending drug in people WITHOUT diabetes.Read the entire article | Email this article
Friday, October 14, 2011
Intensive glucose-lowering treatment resulted in 4% HIGHER risk of death according to meta-analysis
The total risk of death was 4% HIGHER in those given intensive glucose-lowering treatment compared to those who were not given these treatments, however, the difference was not statistically significant, meaning this difference may be due to random chance. Read the entire article | Email this article
Intensive glucose-lowering treatment INCREASED the risk of congestive heart failure by 47%
Thursday, October 13, 2011
Metformin reduced the risk of death by 36% over 10.7 years in Type 2 diabetics
Metformin plus a sulphonylurea increased the risk of death 96% over 10.7 years in Type 2 diabetics
Metformin alone was the only diabetes drug to reduce the risk of death.Read the entire article | Email this article
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