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Tuesday, May 22, 2018

PROTON PUMP INHIBITORS (PPI’s)

Proton pump inhibitors (PPI’s) increase risk of major depression as much as 2-fold

Proton pump inhibitors (PPI’s) increase the risk of major depression according to a study from Taiwan.

People taking 31-120 doses per year were 10% more likely (1.1 times more likely) to have major depression than non-users.

(This difference did not quite reach statistical significance, but was very close—close enough for me.)

People taking 121-365 doses per year were 61% more likely (1.6 times more likely) to have major depression than non-users.

People taking more than 365 doses per year were 108% more likely (2.1 times more likely) to have major depression than non-users.

The risk of subsequent major depression after starting various PPI’s is shown below.

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Posted by Larry Hobbs on Tue, May 22, 2018 8:16 am | [0] comments

PROTON PUMP INHIBITORS (PPI’s)

Proton pump inhibitors (PPI’s) increase risk of Alzheimer’s by 44%

Patients 75 years and older taking a proton pump inhibitor (PPI) were 38% more likely to have any type of dementia and 44% more likely to have Alzheimer’s than non-users according to a study from Germany.

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Posted by Larry Hobbs on Tue, May 22, 2018 7:37 am | [0] comments

Monday, October 24, 2016

PROTON PUMP INHIBITORS

Proton pump inhibitors increase the risk of dementia by 44% according to German study

Regular use of proton pump inhibitors (PPI’s) in the elderly were associated with a 44% greater risk of dementia according to an analysis from researchers at the German Center for Neurodegenerative Diseases in Bonn, Germany.

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Posted by Larry Hobbs on Mon, Oct 24, 2016 10:00 am | [0] comments
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