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Wednesday, August 17, 2016

DRUG COMPANY LIES

Drug adverse events were under-reported 3- to 33-fold in studies of weight loss drug orlistat

Published studies of the weight loss drug orlistat (Xenical and Alii) under-reported adverse events 3- to 33-fold compared to the number of investigator-reported adverse events even though six of seven papers stated that “all adverse events were recorded” according to an analysis of orlistat studies by Prof. Peter Gotzsche, MD and others from the Cochrane Collaboration.

Do you believe that this is also true for studies of cholesterol drugs (statins) and blood pressure drugs and diabetes drugs and antidepressants and anti-anxiety drugs and sleeping pills and bone-building drugs and acid-blocking drugs and every other drug out there?

Yes, of course it is.

I believe that drug-induced side effects are dramatically underreported in all drug studies sponsored by the drug companies.

This is just one example of this.

Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Aug 17, 2016 10:27 am | [0] comments

DRUG COMPANY LIES

1318 drug-induced adverse events were not reported in published study of weight loss drug orlistat

“For one trial [of the weight loss drug orlistat (Xenical, Alii)], we identified an additional 1,318 adverse events that were not listed or mentioned in the [clinical study reports] itself [or the published paper] but could be identified through manually counting individual adverse events reported in an appendix, ” according to an analysis of orlistat studies by Prof. Peter Gotzsche, MD and others from the Cochrane Collaboration.

Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Aug 17, 2016 10:20 am | [0] comments

DRUG COMPANY LIES

Multiple episodes of drug adverse events were only counted once & NOT reported in published studies

“We discovered that the majority of patients [given the weight loss drug orlistat (Xenical, Alii)] had multiple episodes of the same adverse event that were only counted once, though this was not described in the [clinical study reports] [or the published paper],” according to an analysis of orlistat studies by Prof. Peter Gotzsche, MD and others from the Cochrane Collaboration.

Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Aug 17, 2016 10:10 am | [0] comments

DRUG COMPANY LIES

Patients given orlistat had twice as many days with adverse events, but this was not reported

“We also discovered that participants treated with orlistat experienced twice as many days with adverse events as participants treated with placebo… Furthermore, compared with the placebo group, adverse events in the orlistat group were more severe... [however] None of this was stated in the [clinical study reports] or in the published paper,” according to an analysis of orlistat studies by Prof. Peter Gotzsche, MD and others from the Cochrane Collaboration.

Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Aug 17, 2016 10:00 am | [0] comments

Wednesday, December 12, 2012

XENICAL & ALLI (ORLISTAT)

Xenical and Alli increase toxicity of liver and kidneys, and reduces effectiveness of cancer drugs

Orlistat, which is the active ingredient found in the weight loss drugs Xenical and Alli, inhibits a key enzyme, increases toxicity of the liver and kidneys, and reduces effectiveness of some anti-cancer drugs according to a study by Professor Bingfang Yan which was funded by the U.S. National Institutes of Health.

Yan notes that this inhibition occurs with a low level of the drug.

He also notes that “Since it has been available over–the-counter, there has been a drastic increase of toxicity among patients using the drug,” Yan said.

“It has been linked to severe liver failure, acute pancreatic failure and acute renal (kidney) failure.”

Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Dec 12, 2012 5:13 pm | [0] comments

Monday, April 30, 2012

LIRAGLUTIDE

People given 2.4 to 3 mg of liraglutide per day maintained weight loss of 17.6 lbs after two years

People given either 2.4 mg or 3 mg of liraglutide per day maintained a weight loss of 17.6 lbs after two (2) years according to a recent study from Denmark. Liraglutide (brand name Victoza) is a human GLP-1 analog that is a once-daily injectable medication. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Apr 30, 2012 10:10 am | [0] comments

LIRAGLUTIDE

People given 3 mg of liraglutide per day lost 8.4 lbs more after one year than with orlistat

People given 3 mg of liraglutide per day lost 8.4 lbs more after one (1) year than those given the fat-blocking drug, orlistat, according to a recent study from Denmark. Liraglutide (brand name Victoza) is a human GLP-1 analog that is a once-daily injectable medication. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Apr 30, 2012 9:35 am | [0] comments

LIRAGLUTIDE

People given 3 mg of liraglutide per day lost 7.3 lbs more after two years than with orlistat

People given 3 mg of liraglutide per day lost 7.3 lbs more after two (2) years than those given the fat-blocking drug, orlistat, according to a recent study from Denmark. Liraglutide (brand name Victoza) is a human GLP-1 analog that is a once-daily injectable medication. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Apr 30, 2012 9:30 am | [0] comments

Monday, March 15, 2010

XENICAL AND ALII

FDA reviewing safety of Xenical and Alii (orlistat) regarding reports of liver-related problems

The US Food and Drug Administration (FDA) "is reviewing new safety information regarding reports of liver-related adverse events in patients taking orlistat. Orlistat is marketed in the United States as a prescription product, Xenical, and as an over-the-counter (OTC) product, Alli." Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Mar 15, 2010 9:32 am | [0] comments

Friday, April 24, 2009

XENICAL

Xenical (orlistat) used by 43% of weight loss doctors surveyed

Forty-three percent (43%) of weight loss doctors surveyed use the fat-blocking diet drug Xenical (orlistat).

It is the fifth most used diet drug used by these doctors. Read the entire article | Email this article
Posted by Larry Hobbs on Fri, Apr 24, 2009 8:14 am | [0] comments

Monday, November 10, 2008

XENICAL

Xenical (orlistat) plus lifestyle changes caused weight loss of 18.3 lbs (8%) after six months

People given Xenical (orlistat) plus lifestyle changes lost an average of 18.3 pounds or 8 percent of body weight after six months according to a recent review paper. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Nov 10, 2008 11:22 am | [0] comments

XENICAL

Xenical (orlistat) plus lifestyle changes caused weight loss of 16 lbs (7%) after one year

People given Xenical (orlistat) plus lifestyle changes lost an average of approximately 16 pounds or 7 percent of body weight after one year according to a recent review paper. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Nov 10, 2008 11:16 am | [0] comments

XENICAL

Xenical (orlistat) plus lifestyle changes caused weight loss of 16 lbs (7%) after two years

People given Xenical (orlistat) plus lifestyle changes lost an average of approximately 16 pounds or 7 percent of body weight after two years according to a recent review paper. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Nov 10, 2008 11:07 am | [0] comments

XENICAL

Xenical (orlistat) plus lifestyle changes caused weight loss of 12 lbs (5.3%) after three years

People given Xenical (orlistat) plus lifestyle changes lost an average of approximately 12 pounds or 5.3 percent of body weight after two years according to a recent review paper. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Nov 10, 2008 11:01 am | [0] comments

Wednesday, October 08, 2008

XENICAL

Xenical and Alii (orlistat) may increase appetite and food consumption

Orlistat, which includes both the prescription drug Xenical and over-the--counter drug Alii, reduce secretion of appetite-reducing hormones in the gut, which could increase appetite according to a new study from researchers at St. Josef-Hospital at Ruhr-University in Bochum, Germany. Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Oct 08, 2008 11:34 am | [0] comments

Monday, August 11, 2008

XENICAL

People lost 31.7 lbs on very-low-calorie diet, regained 5.3 lbs less in 3 years with Xenical

Obese men and women lost an average of 31.7 pounds on a very-low-calorie diet containing 400 to 800 calories per day. Those given Xenical (orlistat) regained 5.3 pounds less over the next three year than those given a placebo according to a study from researchers at Aarhus University Hospital in Aarhus, Denmark. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Aug 11, 2008 1:04 pm | [0] comments

XENICAL

Women given Xenical maintained greater weight loss after 3 years: 21.3 lbs vs 13.9 lbs

After losing weight for two months on a very-low-calorie diet, women given Xenical (orlistat) maintained an additional 7.5 pounds weight loss after three years compared to women who were given a placebo according to a study from Denmark. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Aug 11, 2008 12:46 pm | [0] comments

XENICAL

Men given Xenical maintained similar weight loss after 3 years: 19.6 lbs vs 17.8 lbs

After losing weight for two months on a very-low-calorie diet, men given Xenical (orlistat) only maintained an additional 1.8 pounds of weight loss after three years compared to men who were given a placebo according to a study from Denmark. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Aug 11, 2008 12:38 pm | [0] comments

XENICAL

Xenical reduced development of type 2 diabetes after 3 years: 5% vs 11%

After losing weight for two months on a very-low-calorie diet, fewer people given Xenical (orlistat) developed type 2 diabetes after three years compared to those given a placebo (5.2 percent versus 10.9 percent) according to a study from Denmark. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Aug 11, 2008 12:23 pm | [0] comments

Friday, June 13, 2008

ALLI

4 million its of Alli (orlistat) sold in the US during its first year on the market

After being on store shelves for one year, GlaxoSmithKline said it sold 4 million kits of Alli (orlistat) in the US. Alli is the only over-the-counter weight loss drug approved by the US Food and Drug Administration (FDA). Read the entire article | Email this article
Posted by Larry Hobbs on Fri, Jun 13, 2008 4:36 pm | [0] comments

Tuesday, June 03, 2008

MERIDIA / XENICAL

Meridia (sibutramine) causes an average weight loss of 4.8 lbs greater than Xenical (orlistat)

Meridia (sibutramine) causes an average of 4.8 pounds greater weight loss than Xenical (orlistat) according to a comparison of eight studies involving a total of 885 patients that compared the two drugs. The studies lasted from 3 to 12 months. Read the entire article | Email this article
Posted by Larry Hobbs on Tue, Jun 03, 2008 3:23 pm | [0] comments

Tuesday, December 18, 2007

XENICAL

2.1% of Xenical users stop taking the drug within 3 months due to diarrhea

The most common reason for stopping Xenical (orlistat) within the first three months was diarrhea, causing 2.1 percent of patients to stop taking the drug according to data from the UK. Read the entire article | Email this article
Posted by Larry Hobbs on Tue, Dec 18, 2007 8:14 am | [0] comments

MERIDIA & XENICAL

80% of people taking Meridia and Xenical are women according to British data

Approximately 80 percent of people taking Meridia (sibutramine) and Xenical (orlistat) are women according to prescription data from the UK. Read the entire article | Email this article
Posted by Larry Hobbs on Tue, Dec 18, 2007 8:05 am | [0] comments

Friday, November 16, 2007

XENICAL

Xenical (orlistat) causes an average weight loss of 6.4 lbs more than placebo

Xenical (orlistat) causes an average weight loss of 6.4 pounds more than placebo or 2.9 percent of body weight more than placebo according to an analysis by researchers from the University of Alberta in Edmonton, Alberta, Canada. Read the entire article | Email this article
Posted by Larry Hobbs on Fri, Nov 16, 2007 10:52 am | [0] comments

Wednesday, October 03, 2007

LONG-TERM MERIDIA & XENICAL USE

Less than 10% of people take Xenical or Meridia for a year; less than 2% take them for 2 years

Less than 10 percent of patients prescribed either Xenical (orlistat) or Meridia (sibutramine) are still taking them after one year, and less than 2 percent are still taking them after two years according to a study from the University of Alberta Hospital in Edmonton, Alberta, Canada. Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Oct 03, 2007 5:27 am | [0] comments

Tuesday, August 14, 2007

ALII

Alii blocks 25% of dietary fat and causes weight loss of 5%

The over-the-counter fat blocker, Alii (60 mg of orlistat), blocks the absorption of about 25 percent of dietary fat and causes a weight loss of about 5 percent of body weight in the first four months according to a review paper by J. W. Anderson from the University of Kentucky's College of Medicine in Lexington, Kentucky, USA. Read the entire article | Email this article
Posted by Larry Hobbs on Tue, Aug 14, 2007 1:06 pm | [0] comments

Monday, July 16, 2007

XENICAL

One year weight loss with Xenical vs placebo: 19.3 lbs vs 12.8 lbs

Patients who were instructed to eat a reduced-calorie diet and were given Xenical (orlistat) lost 6.5 pounds more after one year than those given a placebo -- 19.3 pounds versus 12.8 pounds -- according to a 1999 study by Steven B. Heymsfield, M.D., of the Obesity Research Center at St. Luke's-Roosevelt Hospital in New York and colleagues. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Jul 16, 2007 9:09 am | [0] comments

XENICAL vs ALLI

Two year weight loss with Xenical vs Alli vs placebo: 12.3 lbs vs 9.9 lbs vs 6.9 lbs

After patients had lost an average of 19.3 pounds with Xenical (orlistat) plus a reduced-calorie diet, half of them continued taking Xenical (120 mg of orlistat) three times per day plus a weight maintenance diet for another year, while the other half of patients were given Alli (60 mg of orlistat) instead. Weight loss at the end of the second year was 12.3 pounds for those who kept taking Xenical (120 mg of orlistat) versus 9.9 pounds for those given Alli (60 mg of orlistat) compared to 6.9 pounds for those who were switched from Xenical to a placebo. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Jul 16, 2007 8:23 am | [0] comments

Friday, July 13, 2007

ALLI

Alli, the new OTC fat blocker? Flushing out the Truth. A doctor’s perspective.

As a physician who has committed the past 15 years of my professional career to the medical treatment of overweight and obese patients, I feel the need to express my concern over Alli, the recently FDA approved OTC "fat blocker", and with GlaxoSmithKline, the pharmaceutical company who owns it.
Read the entire article | Email this article
Posted by Robert Skversky, MD on Fri, Jul 13, 2007 1:34 am | [9] comments

Monday, February 12, 2007

XENICAL / ALII

Orlistat (Xenical and Alii) increase weight loss 0.4 lbs per week

Orlistat (Xenical and Alii) is a diet pill that prevents the absorption of approximately one-third of dietary fat. Studies lasting 3 months have found that it increases weight loss by approximately 0.4 lbs per week which is nearly as much as to 0.5 lbs seen with other prescription diet pills, however, it does not reduce appetite like other weight loss medications.
Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Feb 12, 2007 9:45 am | [2] comments

XENICAL / ALII

Orlistat (Xenical and Alii) increase weight loss by 4-5 lbs in three months

The fat-blocking drug orlistat (Xenical and Alii) increases weight loss by 4-5 pounds in three months according to two studies. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Feb 12, 2007 9:30 am | [0] comments

XENICAL / ALII

How does orlistat (Xenical and Alii) work?

The fat-blocking drug orlistat (Xenical and Alii) works by inhibiting three enzymes involved in the breakdown of dietary fat which allows fat to be absorbed -- gastric lipase, pancreatic lipase and pancreatic carboxylester lipase. Pancreatic lipase is the key enzyme required for the absorption of dietary fats. Gastric lipase triggers pancreatic lipase, and pancreatic carboxylester lipase is used in the absorption of fat soluble vitamins. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Feb 12, 2007 9:09 am | [0] comments

Friday, February 09, 2007

ALII (ORLISTAT)

U.S. FDA approves over-the-counter sales of Alii (orlistat)

On Thursday, Feb 7th, 2007, the U.S. Food and Drug Administration (FDA) approved a low-dose version of orlistat capsules as an over-the-counter (OTC) weight loss aid for overweight adults. The drug will be produced by GlaxoSmithKline and called Alii. Read the entire article | Email this article
Posted by Larry Hobbs on Fri, Feb 09, 2007 1:46 am | [0] comments

XENICAL / ALII

How effective is Alii (60 mg) vs Xenical (120 mg)?

I received an email asking how effective lower doses of orlistat are, such as the 60 mg found in Alii (orlistat), compared to the 120 mg found in the prescription version, Xenical (orlistat). The research shows that 60 mg three times per day is nearly as effective as 120 mg. The research also shows that doses higher than 120 mg three times per day are no more effective. Read the entire article | Email this article
Posted by Larry Hobbs on Fri, Feb 09, 2007 1:40 am | [3] comments

Friday, November 10, 2006

XENICAL / MERIDIA

Xenical (orlistat) plus Meridia (sibutramine) causes weight loss of 14.9%

Men and women given a combination of Xenical (orlistat) plus Meridia (sibutramine) lost 8 percent in three months and 14.9 percent after six months according to a study from Brazil.
Read the entire article | Email this article
Posted by Larry Hobbs on Fri, Nov 10, 2006 3:18 am | [0] comments

Saturday, September 02, 2006

XENICAL

Xenical (orlistat) may cause pancreatitis in rare cases

Xenical (orlistat) may cause pancreatitis -- inflammation of the pancreas -- in rare cases according to a new case report. Read the entire article | Email this article
Posted by Larry Hobbs on Sat, Sep 02, 2006 3:33 am | [0] comments

Monday, November 14, 2005

XENICAL / BINGE EATING DISORDER

Xenical (orlistat) helps binge eaters lost 7.4% in six months

The fat-blocking drug Xenical (orlistat) in addition to a mildly reduced calorie diet helped obese patient with binge eating disorder lose 7.4 percent of their body weight in six months compared to 2.3 percent for those given a placebo and following the same diet according to a new study from Switzerland. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Nov 14, 2005 7:25 am | [0] comments

Monday, August 29, 2005

PHENTERMINE

Phentermine should be stopped one week before surgery in order to prevent hypertensive crisis

The diet drug phentermine (Adipex, Ionamin, Fastin) should be discontinued one week before any type of surgery in order to prevent the possibility of a hypertensive crisis due to drug interactions according to a case report of a woman who experienced hypertensive crisis during surgery which was thought to be due to her use of phentermine. Read the entire article | Email this article
Posted by Larry Hobbs on Mon, Aug 29, 2005 11:05 am | [0] comments

Friday, July 15, 2005

XENICAL

Xenical (orlistat) helps adolescents lose an average of 13.8 pounds after one year

Xenical (orlistat) helped adolescents lose an average of 13.8 pounds after a year compared to an average weight gain of 9.2 pounds in the control group according to a study from Ataturk University in Erzurum, Turkey. Read the entire article | Email this article
Posted by Larry Hobbs on Fri, Jul 15, 2005 2:47 am | [0] comments

Wednesday, July 06, 2005

DIET VS DRUGS VS SURGERY

Weight loss less than 11 lbs with diet and lifestyle, 11-22 lbs with drugs, and 55-165 lbs w/surgery

When considering only patients who lose at 5 percent of their body weight by the end of weight loss studies, diet and lifestyle changes cause an average weight loss of less than 11 pounds after 2-4 years; weight loss medications cause an average weight loss of 11 to 22 pounds after 1-2 years; and weight loss surgery causes an average weight loss of 55-165 pounds after 2-4 years according to a new review from researchers at McMaster University in Ontario, Canada. Read the entire article | Email this article
Posted by Larry Hobbs on Wed, Jul 06, 2005 7:50 am | [0] comments

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