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  • 0.5 mg of Tesofensine causes six month weight loss of 11.3% vs 2.1% with placebo

    Posted by .(JavaScript must be enabled to view this email address)
    Wednesday, October 29, 2008 9:39 am Email this article
    In addition to a low calorie diet, a dose of 0.5 mg per day of the experimental diet drug Tesofensine caused a weight loss of 11.3 percent of body weight after six months (24 weeks) versus 2.1 percent with diet plus a placebo according to a new study from obesity researcher Arnie Astrup and others.

    In pounds, those given the drug lost 24.9 pounds versus 4.8 pounds for those given the placebo. Drug’s Mechanism of Action

    Inhibits reuptake of serotonin, noradrenaline and dopamine

    Tesofensine works by inhibiting reuptake of serotonin, noradrenaline and dopamine.



    Subjects: 203 obese patients

    The study involved 203 obese patients with a body mass index (BMI) of 30-40.

    The average starting weight of those in the 0.25 mg group was 225.9 pounds versus 229.5 pounds for those in the placebo group.



    Comment: This is a very powerful drug

    This is a powerful drug simply from the fact that the doses used are so small.

    It will be interesting to see the results of longer studies to see if the weight loss can be maintained after six months.

    Studies with serotonin reuptake inhibitors like Prozac (fluoxetine) show weight loss for the first six months, but after a year or so, there is no significant weight loss from before they were given the drug.


    Astrup A, Madsbad S, Breum L, Jensen T, Kroustrup J, Larsen T. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: A randomised, double-blind, placebo-controlled trial. Lancet. 2008 Oct 22, published on-line.


    Prof Arne Astrup
    The Department of Human Nutrition
    Faculty of Life Sciences
    University of Copenhagen
    Rolighedsvej 30
    DK-1958 Frederiksberg, Denmark
    .(JavaScript must be enabled to view this email address)


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