Clozaril (clozapine) associated with weight gain of 9.8 pounds after two-and-one-half months

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Saturday, August 28, 2004 9:15 am Email this article
Clozaril (clozapine) causes an average weight gain of 9.8 pounds after two-and-one-half months of use according to a recent review paper. 250 mg per day causes gain of 6.5 lbs; 500 mg per day, 9.8 lbs

Weight gain is dose related. A dose of 250 mg per day causes an average weight gain of 6.5 pounds after two-and-one-half months, whereas a dose of 500 mg per day causes an average weight gain of 9.8 pounds.

Clozaril (clozapine) is used to treat schizophrenia in patients where other medicine has not worked according to MedlinePlus.

Clozaril (clozapine) is in a class of medications called antipsychotics. It works by decreasing abnormal excitement in the brain.

REFERENCE(S)

Allison D, Mentore J, Heo M, Chandler L, Cappelleri J, Infante M, Weiden P. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 1999 Nov, 156(11):1686-96.

AUTHOR’S CONTACT INFORMATION

D. Allison
Obesity Research Center
St. Luke’s-Roosevelt Hospital
Columbia University College of Physicians and Surgeons
New York, NY 10025, USA
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