Thorazine plus Serentil (mesoridazine) associated with weight gain of 7 pounds after 2.5 months

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Saturday, August 28, 2004 9:26 am Email this article
The combination of Thorazine (chlorpromazine) plus Serentil (mesoridazine) is estimated to cause an average weight gain of 7 pounds after two-and-one-half months according to a recent review paper. Weight gain NOT dose related: 375 mg per day causes gain of 7 lbs; 500 mg per day a gain of 5.4 lbs

Weight gain is not dose related. A dose of 375 mg per day causes an average weight gain of 7 pounds after two-and-one-half months, whereas a dose of 500 mg per day causes an average weight gain of 5.4 pounds.

Thorazine used to treat psychotic disorders

Thorazine (chlorpromazine) is used to treat psychotic disorders and symptoms such as hallucinations, delusions, and hostility according to MedlinePlus.

It also is used to prevent and treat nausea and vomiting, to treat behavior problems in children, and to relieve severe hiccups.

Serentil (mesoridazine) is used to treat the symptoms of schizophrenia and reduce restlessness, anxiety, and tension.

It also can reduce hyperactivity and uncooperativeness.

REFERENCE(S)

Allison D, Mentore J, Heo M, Chandler L, Cappelleri J, Infante M, Weiden P. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry. 1999 Nov, 156(11):1686-96.

AUTHOR’S CONTACT INFORMATION

D. Allison
Obesity Research Center
St. Luke’s-Roosevelt Hospital
Columbia University College of Physicians and Surgeons
New York, NY 10025, USA
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Articles on the same subject can be found here:

• Serentil (mesoridazine)

• Thorazine (chlorpromazine)

• Weight-gaining drugs