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Zyprexa: Switching to Zyprexa Zydis may not cause weight loss according to Dr. Dennis Padla
Wednesday, September 01, 2004 4:11 pm Email this article
A couple of days ago I reported on a study which found that switching from conventional Zyprexa (olanzapine) tablets to orally disintegrating Zyprexa Zydis (olanzapine) tablets caused an average weight loss of 14.5 lbs. Dennis Padla, M.D., a board certified psychiatrist and active member of the American Society of Bariatric Physicians, strongly disagrees with the results of this study. Dr. Padla found it did not work
Dr. Padla, a friend of this site and a person whose opinion I highly respect, found that it did not work.
He said that he tried this several months ago, switching patients from conventional Zyprexa (olanzapine) tablets to orally disintegrating Zyprexa Zydis (olanzapine) tablets, but they did not lose weight.
Dr. Padla does not believe the results of this study
He stated very strongly that he does not believe the results of this study.
Comment: If it were me, I would at least give it a try
I only downside that I can think of to at least giving it a try is that Zyprexa Zydis appears to be roughly 20 percent more expensive than conventional Zyprexa tablets (roughly $8.30 versus $7.00 according to one Canadian pharmacy’s website).
So if it were me, I at least give it try.
Comment: Important to let the drug be absorbed under the tonge
Zyprexa is thought to cause weight gain by tightly binding to and blocking serotonin receptors in the gut, thereby preventing the signal to the brain to say when a person is full.
Therefore, if someone simply sucks on Zyprexa Zydis tablets and swallows the liquid, dissolved or not, it surely has no chance of working because the drug will still bind to and block these receptors in the gut.
The only chance it has of working is if the drug is not swallowed.
The only chance it has of working is if a person lets the Zyprexa Zydis tablets be absorbed under the tongue (sublingually).
If this is not strictly followed, it surely has no chance of working.
Comment: Sublingual use should be emphasized to patients repeated
I think it should be emphasized repeated to patients the importance of letting the Zyprexa Zydis tablets be absorbed under the tongue, and making sure that they understand exactly how the drug causes weight gain.
If this isn’t done, and patients simply suck on the tablets, it is sure not to work.
Comment: Does anyone else have experience with this?
If anyone else has any experience, please let me know.
Dennis Padla is the founder of The Center for Psychiatry and Weight Loss Management
Dr. Padla is founder and Medical Director of The Center for Psychiatry and Weight Loss Management which he established in 1992.
He is one of only three Board-Certified Bariatric (weight loss) Physicians in the State of Michigan.
Dr. Padla is an active committee member with the American Society of Bariatric Physicians and lectures more than 30 times per year on assorted medical and weight loss issues to health professionals.
He has co-authored and presented original weight loss research data at both national and international symposiums.
Additional information about Dr. Padla and The Center for Psychiatry and Weight Loss Management can be found on his website at:
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