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  • Axokine causes weight loss of 10.1 lbs in three months

    Posted by .(JavaScript must be enabled to view this email address)
    Friday, September 10, 2004 6:27 am Email this article
    Axokine caused morbidly obese people to lose an average of 10.1 pounds in three months according to a recent study.

    This compared to a weight gain of 1.3 pounds for the placebo group.

    The drug must be injected

    The drug was not taken as a tablet, but rather had to injected.

    Optimal dose 1 microgram per kg of bodyweight

    The optimal dose was 1 microgram per kg of bodyweight. (A microgram is one-thousands of a mg, in other words 0.001 mg.)

    Side effects: In general, it was well-tolerated

    In general, it was well-tolerated.

    The most common side effects were irritation were the drug was injected, nausea, cough and headache. Cough was reported in 39 percent of patients given 2 mcg per kg of body weight.

    Subjects: 170 people

    The study involved 170 people that were randomized to one of four groups, either placebo or one of three doses of Axokine.

    What is Axokine?

    Axokine is a drug being developing by the drug company Regeneron Pharmaceuticals for the potential treatment of obesity according to their website.

    Axokine is a modified form of a naturally occurring protein, called Ciliary Neurotrophic Factor which signals the satiety center of the brain to decrease food intake.


    Guler H, Ettinger M, Littlejohn T, Schwartz S, Weiss S, Mcllwain H, Heymsfield S, Bray G, Roberts W, Acheson A, Heyman E, Dark C, Vicary C. Axokine?? causes significant weight loss in severely and morbidly obese subjects. Int J Obes Relat Metab Disord. 2001 May, 25(Suppl 2):S111 (abstract P291).

    Articles on the same subject can be found here:


    On Jan 30, 2005 at 6:29 am Anand Stevens wrote:

    . . . . .

    Why is the citation quoted more than 3 years old?

    On Jan 30, 2005 at 7:19 am Larry Hobbs wrote:

    . . . . .

    That's when the study was published.

    Some people asked for more information on Axokine, and this was one of the studies I was able to find.

    There are a ton of interesting studies that are several years old.

    I first look for new studies to review, but when I come across older studies, I want to review them also.

    Please feel free to share your comments about this article.




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