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Meridia causes a weight loss of 15 lbs weight loss in HMO weight loss program
Tuesday, September 14, 2004 7:26 am Email this article
Meridia (sibutramine) caused an average weight loss of 15 pounds after six months in an health maintenance organization (HMO) weight loss program compared to 6.8 pounds for people not taking the drug. Weight loss maintained for 1 year
Weight loss was maintained for at least one year.
Increased heart rate of 1.7 beats per minute
People taking Meridia (sibutramine) had a slight increase in heart rate which averaged 1.7 beats per minute compared to a slight decrease in the nondrug group of -0.4 beats per minute.
The changes are of no clinical significance.
Subjects: 588 obese patients
The study started with 588 obese patients who enrolled in the weight loss program. Patients were randomly assigned to either receive Meridia (sibutramine) as part of the program, or not.
Meridia patients younger and heavier to start
On average, patients in the Meridia group were younger and heavier than the nondrug group when the study began.
Comment: These differences could be responsible for at least some of the additional weight loss in the Meridia group. Other research suggests that younger patients and heavier patients tend to lose more weight with stimulant-type diet pills.
Conclusion: Weight loss similar in HMO setting as in other studies
“In this managed care setting, the effectiveness and safety of sibutramine were similar to those observed in randomized, double-blind clinical efficacy trials,” the authors of the study concluded.
Porter J, Raebel M, Conner D, Lanty F, Vogel E, Gay E, Merenich J. The long-term outcomes of sibutramine effectiveness on weight (lose weight) study: evaluating the role of drug therapy within a weight management program in a group-model health maintenance organization. Am J Manag Care. 2004 Jun, 10(6):369-76.
AUTHOR’S CONTACT INFORMATION
Aventis Pharmaceuticals, Inc
Bridgewater, NJ 08807, USA
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