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  • Tenuate (diethylpropion) causes 13-20 lbs more weight loss short-term, 3.3 lbs less long-term

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    Friday, October 01, 2004 6:00 am Email this article
    According to the longest double-blind, placebo-controlled study, Tenuate (diethylpropion) causes an an average weight loss of 3.3 pounds or 1.5 percent of bodyweight less than placebo according to a recent review paper. 6 month weight loss: 15.4 lbs vs 19.1 lbs

    In the longest double-blind, placebo-controlled diethylpropion study, the group given the drug lost less weight after six months than those given a placebo—15.4 pounds versus 19.1 pounds.

    1 year weight loss: 19.6 lbs vs 23.1 lbs

    The same was true after one year—19.6 pounds versus 23.1 pounds.

    However, this is limited to 30 patients at six months and 5 patients at one year.

    Study #2: 6 month weight loss: 17.2 lbs vs 4.2 lbs

    A shorter-term study found that people given diethylpropion lost considerably more weight after six months than those given a placebo—17.2 pounds versus 4.2 pounds.

    Study #3: 6 month weight loss: 25.7 lbs vs 5.5 lbs

    Another shorter-term study also found that people given diethylpropion lost more weight after six months than those given a placebo—25.7 pounds versus 5.5 pounds.


    Glazer G. Long-term pharmacotherapy of obesity 2000: a review of efficacy and safety. Arch Intern Med. 2001 Aug 13-27, 161(15):1814-24.


    Gary Glazer MD
    Genesee Hospital
    220 Alexander St, Suite 106
    Rochester, NY 14607

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