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    Amantadine reduces Zyprexa-induced weight gain: -0.4 lbs in four months vs +2.8 lbs

    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, December 02, 2004 4:18 am Email this article
    Amantadine (Symmetrel) reduces Zyprexa (olanzapine) -induced weight gain according to a new study. Weight gain or loss after four months: -0.4 lbs vs +2.8 lbs

    Patients who were given 100-300 mg of amantadine in combination with 5-20 mg of Zyprexa (olanzapine) lost 0.4 pounds after four months compared to a weight gain of 2.8 pounds for those given Zyprexa (olanzapine) alone.

    Subjects: 125 patients with schizophrenia or bipolar disorder

    The study included 125 patient with schizophrenia, schizoaffective, schizophreniform, or bipolar disorder.

    Previous study found amantadine caused weight loss in patients who had gained on Zyprexa

    A previous study found that that patents who had gained an average of 16 pounds taking Zyprexa, lost about 8 pounds taking amantadine.

    There are also a number of comments by doctors attached to the previous article.


    Deberdt W, Winokur A, Cavazzoni P, Trzaskoma Q, Carlson C, Bymaster F, Wiener K, Floris M, Breier A. Amantadine for weight gain associated with olanzapine treatment. Eur Neuropsychopharmacol. 2005 Jan, 15(1):13-21.


    Lilly Research Laboratories
    Lilly Corporate Center
    Eli Lilly and Company, Drop Code 4133
    Indianapolis, IN 46285, USA

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