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U.S. NIH’s Obesity Guidelines Part 21: Weight loss improves cholesterol
Wednesday, December 15, 2004 3:15 am Email this article
A weight loss of 5-13 percent from changes in lifestyle is associated with a 0-18 percent reduction in total cholesterol; 2-44 percent reduction in triglycerides; 3-22 percent reduction in LDL-cholesterol; and a 7-27 percent increase in HDL-cholesterol according to the U.S. NIH's Obesity Guidelines (p. 21). Changes are similar for those on diet-alone, exercise-alone, or diet-plus-exercise. (p. 34) Xenical may decrease cholesterol, but increase triglycerides
One study with Xenical (orlistat) found a decrease in total cholesterol, but an increase in triglycerides.
Other Xenical studies have shown modest improvements in blood lipids with weight loss. (p. 35)
Meridia does not improve blood lipids independent of weight loss
In a rare instance, I consider the report’s statement about Meridia and blood lipids to be misleading. The report states that Meridia is associated with greater weight loss and improvements in blood lipids over placebo. (p. 35) This is true, however, comparing patients with similar weight losses has revealed that the changes in blood lipids are less favorable in patients taking Meridia than those taking placebo.
No long-term studies with other diet drugs to determine effect on blood lipids
No long-term studies using other weight loss medicines such as phentermine, diethylpropion, mazindol, phenylpropanolamine, or ephedrine and caffeine were available for analysis of their effect on blood lipids.
Belly fat associated with blood lipids
A reduction in abdominal fat is associated with an improvement in blood lipids. However, this has not been shown to be independent of weight loss. (p. 35)
Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults : the evidence report / National Heart, Lung, and Blood Institute [Bethesda, Md.] : National Institutes of Health, National Heart, Lung, and Blood Institute, . NIH publication No. 98-4083.
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