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5-HTP causes 4.6 lbs weight loss in two weeks, 11 lbs loss in three months
Thursday, March 24, 2005 10:35 am Email this article
Below is a brief review of the research on 5-HTP when used for weight loss as described in a new paper by Jason Halford from Kissileff Laboratory for the Study of Human Ingestive Behaviour at the University of Liverpool in Liverpool, England, and John Blundell from the Institute of Psychology at University of Leeds in Leeds, England.
These are direct quotes from the paper so that you can read what they have written.
5-HTP reduces food intake
“The [serotonin] precursor, 5-HTP, has been shown to produce potent effects on self reported food intake in the obese,” they write (p. 205, col. 1)
3 month study, 900 mg per day
“In a twelve week study twenty obese individuals, defined as ‘hyperphagics’ [overeaters] were treated with either 5-HTP (900 mg [per day]) or placebo .” (p. 205, col. 1)
[Comment: This is a very large dose. Most doctors who use 5-HTP recommend 100 mg per day, some a little more.]
No diet the first 6 weeks
“During the first six weeks of the study the participants were given no diet regime.” (p. 205, col. 1)
Diet the second 6 weeks
“During the second six weeks of the study all participants were prescribed a diet.” (p. 205, col. 1)
Patients recorded food intake
“All participants recorded their food intake in a diary at regular intervals before treatment commenced and during the non-diet and diet phases.” (p. 205, col. 1)
Weight loss: 11 lbs with 5-HTP vs 2.6 lbs with placebo
“During the treatment those receiving 5-HTP lost [11 pounds] in body weight from baseline ([3.7 pounds] in the non-diet phase and [7.3 pounds] in the diet phase) compared to a non-significant reduction in body weight of [2.6 pounds] seen in those receiving placebo for 12 weeks [3 months].” (p. 205, col. 1)
5-HTP reduced calorie intake 41% during non-diet phase vs 14% with placebo; 60% during diet phase with 5-HTP vs 24% with placebo
“Those receiving the drug reported significant decreases in daily energy intake of 41% ([1346 calories]) in the non-diet phase and 60% ([1959 calories]) in the diet phase from baseline (reductions in self reported food intake in the placebo group were 14% and 24% respectively).” (p. 205, col. 1)
A second shorter study found similar resultso
“In a shorter study the same group replicated their original findings.” (p. 205, col. 1)
A second shorter study found similar results: 750 mg of 5-HTP per day
“In a two week study 25 overweight type 2 diabetics were randomly allocated to receive either placebo or 5-HTP (750 mg [per day]).” (p. 205, col. 1)
“Again diet diaries were used.” (p. 205, col. 1)
5-HTP: 4.6 lbs weight loss in two weeks
“In the 5-HTP treated group weight loss from baseline was [4.6 pounds] over the two weeks.” (p. 205, col. 1)
5-HTP reduced calorie intake by 21-22% or 406-422 calories per day
“This was accompanied by significant decreases of self reported energy expenditure of 21% ([406 calories]) on day 7 and of 22% ([420 calories]) on day 14.” (p. 205, col. 1)
“Examining these figures it is likely there was much underreporting of energy intake by participants in the trial as a whole. However, hypophagia [under eating] does appear to be associated with weight loss.” (p. 205, col. 1)
Here are some previous findings about 5-HTP.
A study from Japan found that 5-HTP increases leptin, the hormone that is released by fat cells with reduces appetite and may or may not increase metabolism.
They also found that 5-HTP did not increase leptin when given with carbidopa.
One study found 5-HTP was eight times more effective at reducing stress-induced eating in rats than reducing eating in rats that had not been fed.
Dr. Michael Anchors sometimes adds 100 mg of 5-HTP to patients taking Phen-Pro, the combination of phentermine combined with Prozac or other certain SSRI’s, when the patient seems to have plateaued, or sometimes uses 5-HTP instead of Prozac or an SSRI.
Dr. Anchors has found that 5-HTP seems to help women more than men. Dr. Dennis Padla, as discussed below, reports the same thing.
Dr. Anchors has found that 5-HTP works better without carbidopa and is better tolerated alone. Some researchers initially theorized that the opposite would be true.
Dr. Richard Rothman gives patients 5-HTP in combination with phentermine.
Dr. Rothman also adds carbidopa, which most other doctors do not.
Dr. Jay Piatek has found that 5-HTP reduces sweet cravings, and often adds it to patients who are taking phentmerine but still have crave sweets. He has also found that only about 10 percent of men crave sweets and that usually 50 mg per day of 5-HTP is enough, whereas about 80 percent of women crave sweets, and more than 50 mg per day is usually required for them.
Dr. Piatek has patients “start with 50 mg in the evening between dinner and bedtime.
“After a week they increase it to 100 mg in the evening if needed.
“Then after five days, if they continue to be hungry or have sweet cravings, I add 50 mg in the morning in addition to the 100 mg in the evening.
“I allow them to increase it by 50 mg every five days, if necessary, first increasing the evening dose and then increasing the morning dose to a maximum of 300 mg per day—150 mg in the morning and 150 mg in the evening.
“I have them adjust the dose until they get a feeling of fullness and eliminate their sweet cravings.”
Dr. Dennis Padla sometimes adds 5-HTP—50 mg, 100 mg, 200 mg or 300 mg—along with 50 mg of vitamin B6 (to help with conversion to serotonin) to patients who have plateaued taking one of the Phen-Pro combinations—phentermine plus Prozac (fluoxetine) or certain other SSRIs.
Dr. Padla says it helps about 30-40 percent of the time, however, it may also increase the incidence of some side effects.
Dr. William Wilson sometimes adds 5-HTP to phentermine and drugs such as Celexa (citalopram) in patients with serotonin deficiency.
In his book “5-HTP: The Natural Way to Boost Serotonin and Overcome Depression, Obesity, and Insomnia” Naturopathic doctor Michael Murray recommends 50 to 100 mg of 5-HTP three times a day 20 minutes before meals, but says that it varies.
Halford J, Harrold JA, Lawton C, Blundell J. Serotonin (5-ht) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets. 2005 Mar, 6(2):201-13.
AUTHOR’S CONTACT INFORMATION
Kissileff Laboratory for the Study of Human Ingestive Behaviour
Department of Psychology
University of Liverpool, Eleanor Rathbone Building
Bedford Street South
Liverpool, L69 7ZA, UK
Tel: + 44 (0) 151 794 2952
Fax: + 44 (0) 151 794 2945
PsychoBiology Group, School of Psychology
Department of Psychology, University of Leeds
Leeds LS2 9JT, U
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On May 29, 2007 at 3:11 am Patricia Wheller wrote:
. . . . .
Where can I buy a good grade and purity 5 HTP?
On May 29, 2007 at 3:24 am Larry Hobbs wrote:
. . . . .
5-HTP is available from "The Store" on this site.
Many other companies sell 5-HTP as well.
The 5-HTP that I sell is from a German source, which is the best available.
There is also 5-HTP made in Switzerland which is also good.
Many companies use Chinese 5-HTP because it is a lot cheaper.
If you are looking to buy a product made with the German 5-HTP or the Swiss 5-HTP, you'd have to ask each company which source they use. Some companies may tell you, but other may not.
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