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  • Leptin nasal spray better at reducing appetite and leptin injections

    Posted by .(JavaScript must be enabled to view this email address)
    Wednesday, April 13, 2005 4:30 am Email this article
    Nasal administration of leptin reduced appetite in rats better than when it was injected into the gut according to anew study from Japan.

    Leptin is a hormone released by fat cells that reduce appetite and, in animals, increases metabolism.

    Nasal administration directly to the brain

    There are blood vessels in the nose that allow the drug go directly to the brain.

    Nasal administration reduced appetite up to 6 hours vs 1 hour when injected

    Rats that were given leptin through the nose reduced their food intake for the first hour and also 3 to 6 hours later compared to leptin injected into the gut only reducing food intake during the first hour.

    Human studies have given leptin as an injection under the skin.

    Other articles about leptin

    Other articles about leptin can be found here


    Shimizu H, Oh-I S, Okada S, Mori M. Inhibition of appetite by nasal leptin administration in rats. Int J Obes Relat Metab Disord. 2005 Apr 12.


    Department of Medicine and Molecular Science
    Gunma University Graduate School of Medicine
    Maebashi, Gunma, Japan

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