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  • Wellbutrin (bupropion) causes average weight loss of 6.1 lbs after six months to one year

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    Monday, April 25, 2005 9:42 am Email this article
    Wellbutrin (bupropion) causes an average weight loss of 6.1 pounds more than placebo after six months according to a analysis by the RAND Corporation. Total weight loss: 9.8 lbs vs 3.7 lbs

    Total weight loss in those given Wellbutrin (bupropion) was 9.8 pounds versus 3.7 pounds for those given a placebo.

    Side effects

    Side effects of Wellbutrin (bupropion) included dry mouth which was 3 times more common than normal, and increases in diarrhea, constipation, and insomnia.

    Three study

    Their analysis included 3 studies.

    Doses: 300-400 mg per day

    One study used 300 mg and 400 mg per day. The other two studies used 400 mg per day.

    This analysis only included data from 400 mg.


    Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman L, Hilton L, Suttorp M, Solomon V, Shekelle P, Morton S. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005 Apr 5, 142(7):532-46.


    Southern California Evidence-Based Practice Center
    RAND Health Division
    1776 Main Street
    Santa Monica, CA 90401-3208
    Tel: 310-393-0411
    Fax: 310-393-4818

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