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Zoloft (sertraline) is not effective at helping to maintain weight loss, may cause weight gain
Tuesday, April 26, 2005 6:30 am Email this article
Zoloft (sertraline) is not effective at helping to maintain weight loss, and actually increases weight regain according to a analysis by the RAND Corporation. Zoloft increased the amount of weight regained following weight loss: +39 lbs vs +26 lbs
Following weight loss on a very low calorie diet and behavior modification, women given Zoloft (sertraline) regained 13 pounds more than women given a placebo.
Women given Zoloft (sertraline) regained 38.9 pounds compared to 26 pounds for women given a placebo.
In other words, Zoloft (sertraline) did not reduce weight gain. It increased it.
Their analysis only included 1 study.
Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman L, Hilton L, Suttorp M, Solomon V, Shekelle P, Morton S. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005 Apr 5, 142(7):532-46.
AUTHOR’S CONTACT INFORMATION
Southern California Evidence-Based Practice Center
RAND Health Division
1776 Main Street
Santa Monica, CA 90401-3208
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