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    Increasing the dose of Glucophage (metformin) increases weight loss in women with PCOS


    Posted by .(JavaScript must be enabled to view this email address)
    Monday, May 16, 2005 3:37 pm Email this article
    Obese women with polycystic ovary syndrome (PCOS) lost an average of 4.6 pounds more when given a 2250 mg of Glucophage (metformin) compared with 1500 mg per day according to a new study from Glasgow, Scotland. In obese women, 2550 mg per day, 7.9 lbs vs 3.3 lbs with 1500 mg per day

    Women who were given 2550 mg of Glucophage (metformin) per day had lost 7.9 pounds after eight months compared to 3.3 pounds for women given only 1500 mg per day.

    Only true for obese women with BMI 30-37

    This was true for obese women with a body mass index (BMI) of between 30 and 37, however, weight loss was similar regardless of dose in morbidly obese women, defined in this study as having a BMI of 37 or more.

    Metformin dose did not affect morbidly obese women with BMI 37+

    The morbidly obese women given 2550 mg of metformin per day lost 8.4 pounds compared to 8.6 pounds for those given 1500 mg per day.

    REFERENCE

    Harborne L, Sattar N, Norman J, Fleming R. Metformin and weight loss in obese women with polycystic ovary syndrome (pcos): comparison of doses. J Clin Endocrinol Metab. 2005 May 10.

    AUTHOR’S CORRESPONDENCE

    University Departments of Obstet. Gynecology and Vascular Biochemistry
    Level 3 (Level 4)
    Q.E.B.
    Royal Infirmary
    Glasgow G31 2ER, UK

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