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Alpha lipoic acid increases fat oxidation
Monday, August 16, 2010 10:01 am Email this article
Alpha lipoic acid increases fat oxidation and reduces the accumulation of fat in muscles according to research from Korea.
A previous study found that alpha lipoic acid causes “profound weight loss” in rodents .
Comments: My personal experiment with Lipoic Acid
I’ve taken acetyl-L-carnitine and alpha lipoic acid since about 2000.
Several years ago after reading about how large doses of alpha lipoic acid causes “profound weight loss in rodents”, I decided to increase my dose.
Comments: I quadrupled my dose of Lipoic Acid to 1000 mg per day
I double my dose from 250 mg twice a day to 500 mg twice a day, then tripled my dose to 750 mg twice a day, then quadrupled my dose to 1000 mg twice a day.
Comments: I switched to R-Lipoic Acid which was at least twice as strong
I then switched from R,S-alpha lipoic acid—the cheaper kind found in most supplements—to R-alpha lipoic acid which is the active form, which seems to be at least twice as potent mg for mg.
Comments: I noticed much more energy and sweating with higher doses
I definitely noticed more energy and more sweating while while exercising as I increased the dose.
Comments: I developed a respiratory infection
However, I developed a cough, which I assume was a respiratory infection, almost immediately that would not go away.
Comments: Lipoic Acid inhibits conversion of T4 to T3 thyroid hormone
I did some research and found that alpha lipoic acid inhibits the enzyme that converts the storage form of thyroid hormone, T4, to the active form, T3.
Low thyroid function is associated with an increased risk of infections.
I assume alpha lipoic acid may reduce T3 in order to prevent overstimulation.
I also assume that the increased dose of alpha lipoic acid reduced my levels of T3 thyroid hormone which allowed a respiratory infection to take hold and my body not able to fight it off.
Comments: After reducing my dose back to normal I felt a lack of energy and sweating which lasted for months
So after maybe two months, I finally reduced my dose of alpha lipoic acid back to the original form of R,S lipoic acid—regular Alpha Lipoic Acid—and reduced the dose back to the original amont of 250 mg twice a day.
However, I then found it very difficult to get a sweat going while exercising and a lack of energy. This lasted for months.
It was so profound and lasted so long, I even wondered if I had done permanent damage to my nerve endings that release noradrenaline.
I wondered this because research has found that methamphetamine, which releases large amounts of noradrenaline, can cause permanent damage to noradrenaline-releasing neurons.
Fortunately, my sweating during exercise did return to normal after quite a few months.
Comments: I tried R-Dihydro-Lipoic Acid, but it has a unpleasant smell that gets on your breath
I have also recently tried R-Dihydro-Lipoic Acid (150 mg), sold by the Life Extension Foundation, which they say is the true active form of alpha lipoic acid. They say that lipoic acid is converted to R-Dihydro-Lipoic Acid in the body.
However, R-Dihydro-Lipoic Acid has a unpleasant, bitter smell—even when encapsulated—and causes the same bitter, unpleasant smell on my breath for 4 to 5 hours after taking it.
Because of this smell, I only take it when I am not going to be in a social situation for the next 6 hours.
Comments: Be careful if you try large doses of Lipoic Acid
The point of the story is that, according to my experince, large doses of alpha lipoic acid may lower T3 thyroid hormone levels and increase the risk of infection, followed by a long recovery time when the large doses are stopped.
I would recommend caution when experimenting with large doses of alpha lipoic acid.
Lee W, Song K, Koh E, Won J, Kim H, Park H, Kim M, Kim S, Lee K, Park J. Alpha-lipoic acid increases insulin sensitivity by activating ampk in skeletal muscle. Biochem Biophys Res Commun. 2005 May 20.
Division of Endocrinology and Metabolism
Department of Internal Medicine
University of Ulsan College of Medicine
Seoul, Republic of Korea
Articles on the same subject can be found here:
On May 06, 2008 at 2:24 pm Tim wrote:
. . . . .
The LT4- LT3 suppression may be the result of an imbalance in amino acids or particular minerals that play a role at the cellular level of converting LT-4 to LT-3, TSH levels are not altered by lipoic acid in any studies I've seen
On May 06, 2008 at 2:54 pm Larry Hobbs wrote:
. . . . .
I have recently increased my intake of R-Lipoic Acid to 100 mg 2-3 times per day and have not felt the tiredness I felt before.
I take a lot of supplements, and have for 26 years, and very well may have created imbalances as you suggested.
I have had many strange experiences through the years, creating problems by taking too much of one thing which has created a imbalance or deficiency of something else.
I don't think this is well recognized.
Occasionally, a study will come out saying that people with certain conditions or disease who also take supplements fare worse than people who do not take them.
Most vitamin proponents say this is nonsense and say they don't believe the study.
I believe this is effect is real and is due to people creating imbalances by taking too much of one nutrient which, in turn, causes a deficiency of something else.
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