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Xenical (orlistat) reduces weight gain in children and adolescents by 5.7 lbs over one year
Thursday, June 16, 2005 2:30 am Email this article
Xenical (orlistat) combined with diet and exercise reduced weight gain in obese children and adolescents over the next year by 5.7 pounds compared to a placebo according to a new study from British Columbia Children's Hospital in Vancouver, Canada. One-year weight gain: 1.2 lbs vs 6.9 lbs
Those given Xenical (orlistat) gained an average of 1.2 pounds over one-year compared to 6.9 pounds in the group given a placebo.
Adverse effects: Up to half had side effects
Up to half of the children and adolescents given Xenical (orlistat) experienced mild to moderate gastrointestinal tract adverse events.
Subjects: 539 obese adolescents 12-16 yrs-old
The study involved 539 obese adolescents ages 12- to 16-years-old, with a body mass index (BMI) 2 or more units above the 95th percentile for their age and gender, at 32 centers in the U.S. and Canada who were randomly assigned to receive Xenical (orlistat) or a placebo in addition to advice and diet and exercise.
Dose: 120 mg 3 times per day
The dose of Xenical (orlistat) used was 120 mg three times per day before meals.
Chanoine J, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial. JAMA. 2005 Jun 15, 293(23):2873-83.
AUTHOR’S CONTACT INFORMATION
Endocrinology and Diabetes Unit
British Columbia Children’s Hospital
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On Jun 26, 2005 at 9:46 am Randy Smith, MD wrote:
. . . . .
These are good results however the fat soluble vitamin issue needs to be addressed.
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