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Green tea inhibits fat accumulation in fat cells and increases death of mature fat cells
Wednesday, August 10, 2005 6:48 am Email this article
Epigallocatechin gallate (EGCG), the primary health-promoting ingredient in green tea, dose-dependently inhibits accumulation of fat in fat cells, and increases the rate of programmed cell death of mature fat cells according to a new study from researchers at the University of Georgia in Athens, Georgia, USA. Conclusion
Epigallocatechin gallate (EGCG) is a type of polyphenol, more specifically a catechin which is a type of polyphenol.
“EGCG [found in green tea]... could be an important adjunct in the treatment of obesity,” the researchers concluded.
Other studies on the effects of green tea and oolong tea for weight loss can be found here.
Lin J, Della-Fera MA, Baile C. Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3t3-l1 adipocytes. Obes Res. 2005 Jun, 13(6):982-90.
AUTHOR’S CONTACT INFORMATION
444 Edgar L. Rhodes Center for Animal and Dairy Science
University of Georgia
Athens, GA 30602-2771, USA
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On Dec 19, 2005 at 2:57 am carrot wrote:
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I just would like to know which dose is needed for the death of matire fat cells and to inhibit the fat accumulation. I think it should be written here.
On Dec 19, 2005 at 7:23 am Larry Hobbs wrote:
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I don't know what dose of EGCG from green tea is required to kill fat cells.
This study was done by mixing EGCG from green tea with fat cells in a dish -- it's called an "in vitro" study which means that it was done outside the body.
I imagine the concentration they used was fairly high. In studies like this, they use a high dose just to see if anything happens.
I do not know if they tried to determine the lowest concentration of EGCG that would cause this to happen.
Even if we knew the minimum concentration that would cause this to happen, it would be difficult to convert this into a dose that can be taken by mouth to get the same concentration as the study in the body because EGCG from green tea is not absorbed very well from the gut.
I'm sorry, but I don't have an answer for you.
Hopefully the researchers will do a follow-up study and give animals large doses of EGCG from green tea and see if they can achieve doses that kill mature fat cells when given by mouth as it did in this study.
Thanks for your good comment.
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