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    Two-thirds of ephedra-related psychiatric reports occurred in patients with preexisting conditions

    Posted by .(JavaScript must be enabled to view this email address)
    Wednesday, August 31, 2005 6:48 am Email this article
    There have been a number of case reports of psychiatric side effects associated with the use of the herb ephedra. However, "two-thirds of these psychiatric cases involved patients with pre-existing psychological/psychiatric conditions and/or use of other mood-altering medications or illicit substances" according to an analysis by the RAND Corporation of Santa Monica, California. 57 psychiatric case reports out of 1800 total adverse effects from ephedra

    “Out of almost 1800 total adverse events, 57 were classified as both psychiatric in nature and serious,” the researchers noted.

    Most case reports insufficient to determine the cause

    “The majority of case reports were insufficiently documented to make an informed judgment about a relationship between the use of ephedra and the adverse event in question,” they continue.

    Link between ephedra and psychiatric complications

    “The case reports evaluated do not prove a definitive causal link between ephedra and psychiatric complications. However, they do raise concern that such a relationship may exist,” the report concludes.


    Maglione M, Miotto K, Iguchi M, Hilton L, Shekelle P. Psychiatric symptoms associated with ephedra use. Expert Opin Drug Saf. 2005 Sep, 4(5):879-84.


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