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  • One-third of infertile obese women become pregnant after taking metformin (Glucophage)

    Posted by .(JavaScript must be enabled to view this email address)
    Friday, September 09, 2005 3:26 am Email this article
    Approximately one-third (6 out of 19, or 32 percent) of obese women with polycystic ovary syndrome (PCOS) who were infertile before treatment, became pregnant within six months of taking the anti-diabetes drug metformin (Glucophage) according to a study from Amman, Jordan. All women had failed to get pregnant with Serophene (clomiphene)

    Previous treatment with the estrogen-blocking drug clomiphene citrate (Serophene, Clomid) had been unsuccessful in all of these women.

    Metformin 850 mg twice a day

    The women were given 850 mg of metformin (Glucophage) twice a day for six months.

    Significant weight loss

    Treatment with metformin (Glucophage) caused “a significant reduction in the body weight”.

    Unfortunately, I don’t have a copy of this paper and so cannot tell you how much weight the women lost or if the women who became pregnant lost more weight than those who did not.

    Metformin continued during first 3 months of pregnancy

    If the women became pregnant, metformin (Glucophage) was continued for the first 12 weeks of pregnancy.

    Two-thirds started having their periods, one-half started ovulating

    Two-thirds (13 of 19, or 68 percent) of these women resumed having regular menstrual cycles, and nearly one-half (9 of 19, or 47 percent) began ovulating.

    Metformin should be first-line of treatment for infertility in obese women

    “Metformin monotherapy is effective in [clomiphene / Serophene]-resistant women with morbid obesity and primary infertility and should be considered as first-line treatment in these patients,” the researchers concluded.

    Polycystic ovary syndrome affects 10% of women

    “Polycystic ovary syndrome is one of the most common endocrine (hormone-based) disorders in the human, affecting approximately 10% of women of reproductive age,” according to a paper by Lakhani et al (2005).

    Polycystic ovary syndrome associated with insulin resistance

    “Although originally considered a gynaecological disorder, the syndrome is associated with a wide range of endocrine and metabolic abnormalities, including insulin resistance.


    Qublan H, Malkawi H. Metformin in the treatment of clomiphene citrate-resistant women with high bmi and primary infertility: clinical results and reproductive outcome. J Obstet Gynaecol. 2005 Jan, 25(1):55-59.


    Lakhani K, Prelevic G, Seifalian A, Atiomo W, Hardiman P. Polycystic ovary syndrome, diabetes and cardiovascular disease: risks and risk factors. J Obstet Gynaecol. 2004 Sep, 24(6):613-21.


    Ultrasound Department
    North Middlesex Hospital
    London, England

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