QUICKLINKS AND VIEW OPITONS
Phendimetrazine (Bontril): 105 mg three times per day caused 1.7% loss after one-and-a-half months
Monday, February 13, 2006 10:00 am Email this article
A small group of patients were given 105 mg three times per day, but did not lose any more weight after a month-and-a-half than those given 70 mg three times per day. In fact, they lost slightly less weight -- 7.2 percent versus 8.4 percent, respectively.
70 mg three times per day is the most effective dose
This suggests that higher and higher doses do not cause more and more weight loss.
This study found that 70 mg three times per day caused the maximum amount of weight loss.
The idea that “more is not better” is probably true of most drugs
This finding, that giving a higher dose does not necessarily cause greater weight loss, is probably true for most, if not all, drugs.
Drugs have a “therapeutic window”
Studies have found that antidepressants have a “therapeutic window”, meaning that you need a certain amount of the drug to have an effect, but taking too much can have the opposite effect.
Book written about the “therapeutic window” of nutrients
An entire book written on this premise regarding vitamins and minerals called “The Reverse Effect: Vitamins and Minerals Promote Health and Cause Disease” by Walter Heiby (1988).
In it, he suggests that there is a “therapeutic window” for all nutrients, and above this “window”, the opposite effect or “reverse effect” occurs.
He gives example after example after example. It is a very interesting book.
We live in a culture of “more, more, more”
It is my impression that in our culture, as opposed to Asian Cultures, doctors and patients alike tend to think in terms of “more”.
I interviewed one doctor who, when I asked what he did if a patient reached a weight platuea, said he increased their dose of the drug.
When I asked, “What do you do when they still having trouble losing any more weight.” he said he add a second drug and a third drug if necessary.
When I asked what he did if a patient had certain side effects, he said that he add another drug in order to counter the side effects.
My impression was that he believed that the answer to weight loss was more drugs, more drugs, more drugs.
Although I believe some patients may need much higher doses than other patients, higher doses are not always the answer.
Patients were not asked to diet or exercise
Patients in this study were not given any specific dietary recommendations. In other words, there were not told to reduce their calorie intake.
This was done in order to isolate the effect of the drug.
All diet pill studies were done this way back in the 1960’s
Note: This study was performed in 1961. Back then, this is the way that studies were done. Subjects were simply givent the diet drug but were not asked to diet and exercise. It wasn’t until twenty or thirty years ago, that diet pill studies started asking patients to diet and exercise as well.
Cass LJ. Evaluation of phendimetrazine bitartrate as an appetite suppressant. Canadian Medical Association Journal, 1961 May 20;84:1114-6.
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