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Phendimetrazine (Bontril): 35 mg three times per day in type II diabetics: 2.7 lbs in three months
Monday, February 13, 2006 11:13 am Email this article
Type II diabetics given 35 mg of phendimetrazine three times per day one-half hour before meals lost an average of 2.7 pounds in three months. (Runyan, 1962) The patients only lost weight loss during the first month month
This amount of weight loss was achieved after one month with a slight increase after two months but no additional increase after three months. (Runyan, 1962)
Subjects given a placebo gained an average of 0.9 pounds. (Runyan, 1962)
Diet: Instructed to eat 1200-1500 calorie diabetic diet
Patients had been instructed on using a diabetic diet of 1200 to 1500 calorie per day during the past year, but not specific to this study.
Subjects were not told it was a diet pill
Study subjects were not told that they were taking an appetite suppressant.
Instead they were told that the medicine was for their diabetes. (Runyan, 1962)
Subjects: 76 Diabetics
The study involved 76 obese type II diabetics. (Runyan, 1962)
Blood Sugar: No effect
There was no significant difference in blood pressure between patients given phendimetrazine and placebo. (Runyan, 1962)
Blood Pressure: Small decrease
Blood pressure decreased by 6/4 mm Hg in the phendimetrazine group compared to 2/2 mm Hg in the placebo group. (Runyan, 1962)
Adverse Effect: Nausea
Transient nausea occurred in several patients. (Runyan, 1962)
Adverse Effect: Nervousness
Two patients also complained of nervousness. (Runyan, 1962)
No drop outs due to side effects
No one discontinued due to side effects.
Runyan JW Jr. Observations on the use of phendimetrazine, a new anorexigenic agent, in obese diabetics. Curr Ther Res 1962 May;4:270-5.
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