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Phendimetrazine (Bontril) adverse effects: nervousness, insomnia, nausea, increased blood pressure
Monday, February 13, 2006 9:45 am Email this article
The adverse effects of phendimetrazine include nervousness (10 percent of patients), insomnia (5 percent), nausea (3 percent), increased blood pressure (3 percent), dry mouth (3 percent), tachycardia (a racing heart) (2 percent) according to one study. (Young, 1961)
Withdrawals: 3% withdrew due to nervousness
Three percent of patients withdrew from the study due to nervousness. (Young, 1961)
Congestive heart failure: One case associated with phendimetrazine
A thirty-seven-year-old women who had taken 105 mg of phendimetrazine twice a day for seven years developed dilated cardiomyopathy.6 Before hospitalization she had labored breathing during exertion, peripheral edema, and palpitations at rest.
She was severely ill when hospitalized with a rapid heart beat (120 beats per minute) and rapid breathing (24 respirations per minute) and cyanosis (bluish discoloration of the skin).
Her abnormalities resolved almost completely 7 months after discontinuing the drug. (Rostagno et al, 1996)
Interstitial nephritis: One case associated with phendimetrazine
A forty-seven-year-old women taking phendimetrazine and phentermine fell ill after three weeks. (Markowitz et al, 1998)
She was found to have leukocyturia, a rash on her face and chest, and a rise in her serum creatinine from 0.8 mg/dL to 2.1 mg/dL. (Markowitz et al, 1998)
A renal (kidney) biopsy confirmed the diagnosis of acute interstitial nephritis (kidney inflammation).
The patient was treated with corticosteroids and her renal (kidney) function returned to normal. (Markowitz et al, 1998)
Stroke: Phendimetrazine may increase the risk of stroke
Phendimetrazine may increase the risk of inschemic stroke according to a case report. (Kokkinos and Levine, 1993)
Two cases of stroke were reported, one in a patient taking phentermine and another taking phentermine combined with phendimetrazine. (Kokkinos and Levine, 1993)
Death: Three deaths associated with phendimetrazine
Phendimetrazine has been associated with three fatalities. (Hood et al, 1988)
In one case the blood concentration was 300 ng/ml indicating that the person had taken at least four tablets (at least 140 mg). (Hood et al, 1988)
Pulmonary Hypertension: One case of reversible PPH
Phendimetrazine has been associated with one case of Primary Pulmonary Hypertension (PPH). (Nall et al, 1991)
The case involved a 41-year-old woman who developed shortness of breath after taking phendimetrazine for six months. (Nall et al, 1991)
Blood pressure in her lungs was found to be elevated considerably.
An echocardiogram revealed right heart abnormalities and an open-lung biopsy found 2-3 vascular lesions consistent with PPH.
Three months after stopping the phendimetrazine a subsequent echocardiogram revealed no heart abnormalities and blood pressure in the lungs was normal.
This was the first case of reversible diet-drug-associated PPH reported in the United States.
Markowitz GS; Tartini A; D’Agati VD. Acute interstitial nephritis following treatment with anorectic agents phentermine and phendimetrazine. Clinical Nephrology, 1998 Oct, 50(4):252-4.
Rostagno C; Caciolli S; Felici M; Gori F; Neri Serneri GG. Dilated cardiomyopathy associated with chronic consumption of phendimetrazine. American Heart Journal, 1996 Feb, 131(2):407-9.
Young RE. Comparative study of phenmetrazine and phendimetrazine in the management of obesity. Curr Ther Res 1961 Aug;3(8):350-4.
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