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Boosting metabolism: Meridia (sibutramine) raises metabolism in men
Sunday, March 05, 2006 1:16 pm Email this article
Meridia (sibutramine), and I assume other noradrenaline reuptake inhibitors, may increase metabolism slightly. They may increase metabolism in men more than women according to the research.
Meridia increases metabolism 3-5% in normal-weight men
One study found that Meridia (sibutramine) increases metabolism 3 to 5 percent in healthy, normal-weight men.
30 mg of Meridia increases metabolism 2.7% for 5.5 hours
Thirty mg of Meridia increased the number of calories burned during a five-and-one-half period following breakfast more than a placebo the equivalent of 2.7 percent of basal metabolic rate.
After fasting, Meridia increases metabolism 3.6%
After fasting, Meridia increased the number of calories burned the equivalent of 3.6 percent of basal metabolic rate.
Meridia increases metabolism 4% after fasting, 4.8% after eating
For the last three-and-one-half hours after taking Meridia (sibutramine) metabolism increased 4 percent after fasting, and 4.8 percent after a meal.
Similar increase as seen with ephedrine and caffeine
The authors of the study noted that this is similar to the increase in metabolism seen with a usual dose of ephedrine and caffeine.
Comment: This seems overstated to me since ephedrine, caffeine and theophylline were found to increase metabolism by 8 percent per day.
This is the first study to show such an effect in humans.
Previous studies saw no increase, but may have been too short
The authors noted that a previous study which failed to find an increase in metabolism during a three hour period may have been too short to see any significant effect.
No increase seen during first 3 hours
There was no significant effect during the first three hours of the present study also.
Meridia increased heart rate 7-9 beats per minute
Meridia increased heart rate 7 and 9 beats per minute after fasting and a meal, respectively.
The study involved 11 healthy, normal-weight men, used 30 mg of Meridia and a 500 calorie breakfast.
Meridia had no effect on metabolism in women
A study found no difference in metabolism in women given up to 30 mg per day (Seagle et al, 1996 and 1998), however, other studies have found that the decrease in metabolism following weight loss was attenuated when they were given Meridia.
Metabolism dropped less in women taking Meridia following weight loss
A three month study found that resting metabolism dropped less in obese women taking 15 mg of Meridia (sibutramine) than those taking a placebo (-5% vs -9%) although those taking Meridia tended to lose more weight (-8% vs -5%). (Walsh and Lean, 1997)
Seagle HM, Bessesen DH, Hill JO. Chronic effects of Meridia 10 mg and 30 mg on resting metabolic rate in healthy overweight women. Obesity Research, Oct 1996, 4(Suppl 1):31S (abstract O74). Correspondence: HM Seagle, Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262.
Seagle HM, Bessesen DH, Hill JO. Effects of sibutramine on resting metabolic rate and weight loss in overweight women. Obesity Research, Mar 1998, 6(2):115-121.
Walsh KM, Lean MEJ. Effects of sibutramine on energy expenditure in obese females. International Journal of Obesity, 1997 June, 21(Suppl 2):S56 abstract 160.
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