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Topamax plus metformin helped diabetics lose 6.5% of their body weight
Thursday, May 25, 2006 3:24 am Email this article
Type 2 diabetics taking metformin (Glucophage) and Topamax (topiramate) lost 4.5 to 6.5 percent of their body weight after one year compared to 1.7 percent for those taking only metformin (Glucophage) according to a large study from the Medical University in Graz, Austria. Weight Loss
Weight loss after one year: 1.7% with metformin alone, 4.5 percent with metformin plus 96 mg of Topamax, 6.5% with metformin plus 192 mg of Topamax
Subjects given 92 mg of Topamax (topiramate) per day lost 4.5 percent of their body weight, while those given 196 mg of Topamax (topiramate) per day lost 6.5 percent of their body weight.
Blood Sugar Control
HbA1c fell 0.1% in those taking metformin alone, 0.4% in those taking 96 mg of Topamax , and 0.6 percent in those taking 192 mg of Topamax
Levels of HbA1c fell by 0.1 percent in those who continued taking metformin alone, by 0.4 percent in those taking metformin plus 96 mg of Topamax (topiramate), and by 0.6 percent in those taking metformin plus 192 mg of Topamax (topiramate).
(These decreases are in absolute levels, that is to say that if levels fell from 6.6 percent to 6 percent then it would have been a 0.6 percent decrease.)
HbA1c is short for hemoglobin A1c. It is also known as glycated hemoglobin.
The level of HbA1c reflects the average blood sugar level over the past 2 to 3 months.
Normal levels of HbA1c are 4 percent to 5.9 percent.
Subjects: 646 obese men and women
The study involved 646 obese men and women with type 2 diabetes that was controlled by metformin (Glucophage).
Subjects were 18- to 75-years-old and had a body mass index (BMI) of 27 to 50.
The most common adverse effects were a sensation of burning and tingling of the skin and
The most common adverse effects of those given Topamax (topiramate) were paresthesia (a burning or tingling sensation of the skin, a feeling of “pins and needles”) and “events related to the central nervous system” according to the abstract.
Preventing or Treating Topamax-Induced Skin Sensations
Potassium may help prevent or treat Topamax-induced skin sensations according to Dr. Robert Skversky
Zonegran Instead of Topamax?
‘Zonegran is the new and improved Topamax’ according to Dr. Jay Piatek
Anyone interested in using Topamax (topiramate) should read the article by Dr. Jay Piatek about how he has found that Zonegran (zonisamide) works as well as Topamax (topiramate) but with fewer side effects.
There are a lot more studies showing weight loss with Topamax than with Zonegran, but don’t let this convince you that Topamax is better. I assume that this is simply because the drug company making Topamax has spent more money doing weight loss studies to get more exposure.
Toplak H, Hamann A, Moore R, Masson E, Gorska M, Vercruysse F, Sun X, Fitchet M. Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: A randomized, double-blind, placebo-controlled study. Int J Obes (Lond). 2006 May 16.
Department of Medicine
Institute for Diabetes and Metabolism
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