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2.2 lbs weight loss increases appetite by 100 calories per day, long-term weight loss difficult
Friday, October 14, 2016 11:08 am Email this article
Every one kilogram (2.2 lbs) that a person loses, appetite increases by roughly 100 calories per day making long-term weight loss difficult according to a new study from researchers at the U.S. National Institutes of Health.
The chart below from the paper shows that while patients lost very roughly 3.5 kg (7.7 lbs), their appetite increased by roughly 350 calories per day.
Conclusion: Increases in appetite plays a large role in slowing of weight loss and subsequent regain
“While energy expenditure adaptations [decreases in metabolism due to weight loss] are often thought to be the main reason for slowing of weight loss and subsequent regain, feedback control of energy intake [increases in appetite] plays an even larger role and helps explain why long-term maintenance of a reduced body weight is so difficult,” the researchers concluded.
Subjects: 153 people
The study analyzed data for 153 people given the drug canagliflozin for one year, a drug that increases glucose excretion in the urine which results in weight loss without people being aware of the calorie deficit.
Polidori D, Sanghvi A, Seeley R, and Hall KD. How strongly does appetite counter weight loss? Quantification of the homeostatic control of human energy intake. BioRxiv, 2016 Apr 29; Published online at http://biorxiv.org/content/early/2016/04/29/051045.
Author’s Contact Info
Kevin D. Hall, PhD
National Institute of Diabetes & Digestive & Kidney Diseases National Institutes of Health
12A South Drive, Room 4007
Bethesda, MD 20892-5621
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