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Resveratrol prevents diabetes and extends lifespan of rats on high fat, high calorie diet
Tuesday, November 07, 2017 1:42 am Email this article
Resveratrol, a polyphenol found in the skins of red grapes, peanuts, blueberries, bilberries, and cranberries, prevented obesity-related health problems and gave a near-normal lifespan to mice fed a high-fat, high-calorie diet according to a new study from researchers at Harvard Medical School and the National Institute on Aging. Mice given resveratrol were healthier
Mice given resveratrol still got fat just like the mice not given the compound, “but after a year the mice in the resveratrol group seemed a lot healthier than their high-calrie-fed counterparts,” notes an accompanying editorial. (Check, 2006)
Resveratrol prevented diabetes, liver damage and reduced death by 30%
“The drug seemd to prevent thsee mice from developing a diabetes-like illness and liver damage, and reduced their risk of death by 30%, compared with the mice on high-calorie diets that did not get the drug,” Check continues.
Resveratrol has ‘profound ability to prevent liver damage’
One of the problems associated with a high-fat diet is fatty liver disease.
“t is noteworthy that Baur et al. show that resveratrol has a profound ability to prevent liver damage associated with the high-fat diet,” another article notes. (Kaeberlein and Rabinovitch, 2006)
Did not show it could reverse the effects after years of a bad diet
It should be noted that the study did not show that resveratrol was able to reverse the damage done by eating a high-calorie diet, since the mice were taking resveratrol the entire time they were fed the diet.
May work in a manner similar to a calorie-restricted diet
David Sinclair, from the Harvard Medical School, believes that resveratrol works in a manner similar to a calorie-restricted diet.
Calorie-restricted diet increases lifespan by 50%
Back in the 1930, studies showed that feeding mice a diet with 40 percent fewer calories increased life span by as much as 50 percent and delayed nearly all age-related diseases.
Resveratrol increases lifespan in several species
Other studies have found that resveratrol increases lifespan in worms, flies and short-lived fish.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Couteur DL, Shaw RJ, Navas P, Puigserver P, Ingram DK, Cabo RD, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 1.
Rafael de Cabo
Laboratory of Experimental Gerontology
Research Resources Branch of the Gerontology Research Center
National Institute on Aging
National Institutes of Health
5600 Nathan Shock Drive
Baltimore, Maryland 21224, USA
Department of Pathology
Paul F. Glenn Laboratories for the Biological Mechanisms of Aging
Harvard Medical School
77 Avenue Louis Pasteur
Boston, Massachusetts 02115, USA
Check E. A votre santé: Now in pill form? Nature. 2006 Nov 1, page 11.
Kaeberlein M, Rabinovitch P. Grapes versus gluttony. Nature. 2006 Nov 1, pages 1-2.
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