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Xenical (orlistat) plus Meridia (sibutramine) causes weight loss of 14.9%
Friday, November 10, 2006 3:18 am Email this article
Men and women given a combination of Xenical (orlistat) plus Meridia (sibutramine) lost 8 percent in three months and 14.9 percent after six months according to a study from Brazil.
Range of weight loss : 0-27%
Weight loss after three months ranged from +1.5 percent to -24 percent, and after six months from -0.4 percent to 26.6 percent.
Doses : 30 mg of Meridia, 120 mg of Xenical
“Regular doses” of each drug were used, which I assume means 30 mg of Meridia (sibutramine) and 120 mg of Xenical (orlistat).
Subjects : 214 people
The study started with 214 people—121 women and 93 men.
100 people finished three months, 36 completed six months
One hundred people completed 3 months and 36 completed six months.
Side effects : Tolerable
“Tolerability was quite reasonable,” the authors noted.
Mancini M, Halpern A. Pharmacological treatment of obesity. Arq Bras Endocrinol Metabol. 2006 Apr, 50(2):377-89. Study results discussed on page 385, column 2 under “Associations of two pharmacological agents”. The reference to the actual study is not clear in the paper but was performed by the same authors, Mancini and Halpern.
AUTHOR’S CONTACT INFORMATION
Endocrinology and Metabology Division
Hospital das Clinicas, Medical School
University of Sao Paulo
Sao Paulo, SP Brazil
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