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How effective is Alii (60 mg) vs Xenical (120 mg)?
Friday, February 09, 2007 1:40 am Email this article
I received an email asking how effective lower doses of orlistat are, such as the 60 mg found in Alii (orlistat), compared to the 120 mg found in the prescription version, Xenical (orlistat). The research shows that 60 mg three times per day is nearly as effective as 120 mg. The research also shows that doses higher than 120 mg three times per day are no more effective.
The effect of various doses of orlistat (Xenical and Alii)
Here is what the research shows for the effects of various doses of orlistat (Xenical 120 mg and Alii 60 mg).
- 10 mg causes 5% fat excretion
- 12 mg causes 8% fat excretion
- 20 mg causes 17% fat excretion
- 25 mg causes 14-18% fat excretion
- 30 mg causes 21% fat excretion
- 50 mg causes 20-24% fat excretion
- 60 mg causes 30% fat excretion
- 120 mg caused 36% fat excretion
- 200 mg caused 32-35% fat excretion
- 240 mg caused 31% fat excretion
- 400 mg caused 27% fat excretion
Practical advice : Use 60 mg rather than 120 mg to cut your cost
The 60 mg found in the over-the-counter version of orlistat called Alii is nearly as effective as 120 mg found in the prescription version called Xenical (orlistat) and most likely will be less expensive.
Skip the drug if you skip a meal
It is also not necessary to take a dose of Xenical (orlistat) or Alii (orlistat) if you are not going to skip a meal.
Hauptman JB, Jeunet FS, Hartmann D. Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin). American Journal of Clinical Nutrition, 1992 Jan, 55(1 Suppl):309S-313S.
Articles on the same subject can be found here:
On Jan 23, 2007 at 3:25 pm Juche wrote:
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Due to the risk of dumping you are not supposed to take xenical if you eat a high fat meal, something with more than 30% of calories from fat.
However, if you do end up eating a high fat meal (40-50% fat or more. For example I like to eat chicken breast cooked in heart healthy butter which has a fat content of about 50%) would taking a dose like 20mg which only causes 17% fat excretion be viable over not taking xenical at all?
It seems that rather than skipping xenical altogether when a meal is over 30% fat that using a far lower dose that blocks less than 1/3 of the fat in the food would be ideal. This should help with weight management while helping to avoid dumping, but I don't know if studies have been done on it.
On Jan 23, 2007 at 4:14 pm Lord_Humungus wrote:
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I tried to make a comment earlier but I don't know if it went through.
Sometimes I eat very high fat foods. For example, I will cook chicken breasts in heart healthy oil or butter (made out of olive oil, flax oil, etc) and as a result the meal has a fat content of 50% or more.
Since you are not supposed to take xenical with meals higher than 30% fat due to dumping syndrome, what about taking doses of xenical closer to 25mg with extremely high fat meals?
If you eat a meal that is 30% fat and 30% of the fat you eat is blocked at 60mg, then you are losing 9% of your calories from undigested fat.
If you eat a meal that is 50% and 17% of the fat you eat is blocked at 20mg then you are losing 8.5% of your calories from undigested fat.
It seems that doing that, although inconvenient, would be an effective way to take xenical with high fat meals w/o suffering from gastrointestinal problems.
On Jan 25, 2007 at 5:37 am Larry Hobbs wrote:
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I have changed it so that comments will be posted immediately.
I had it so I had to approve all comments because spammers were posting junk every day, but the use of Captcha -- the security code that shows up as an image that you have to enter -- seems to have stopped the spam.
Ragarding when to take Xenical...
I think it is more about how much total fat, in grams, is in the meal .
You could try a lower dose of Xenical with a high fat meal.
You will know quickly if it was a mistake.
I would would only do this type of experience at home with a bathroom close by.
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