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Contrave with varying doses causes 7-8% weight loss in six months, 8-9% in nine months
Friday, March 30, 2007 2:12 am Email this article
Among patients who finished the study, those given Contrave, with higher than 300 mg doses of Wellbutrin (bupropion) and one of three different doses of naltrexone -- I assume less than 50 mg used in the previous study in order to try and reduce nausea -- lost an average of 7 percent to 7.6 percent after six months compared to 1.1 percent for those given a placebo. After nine months, the average weight loss for those still in the study was 8 percent to 9.3 percent. 6 Month Weight Loss
6 month weight Loss for all patients: 4.3% to 5.4% after six months, 4.6% to 6.1% after nine months
Among all patients treated, including those who dropped out of the study early, the average weight loss in the three groups of people given Contrave was 4.3 percent to 5.4 percent after six months compared to 0.8 percent for those given a placebo.
6 Month Weight Loss
9 month weight Loss for all patients: 4.6% to 6.1% after nine months
Among all patients treated, including those who dropped out of the study early, after nine months, the average weight loss in the three groups of people given Contrave was 8 percent to9.3 percent.
Doses: More than 300 mg of Wellbutrin plus more than 50 mg of naltrexone
The dose of Wellbutrin (bupropion) used in this study was more than 300 mg used in the previous study, although I don’t know exactly dose of Wellbutrin (bupropion) used in this study.
This higher dose of Wellbutrin (bupropion) was combined with three different doses of immediate-release naltrexone.
I don’t know the exact doses of naltrexone used in this study, however, I assume they were less than the 50 mg used in the previous study in order to try and reduce the high incidence of nausea.
Side Effects: I don’t know how many reported nausea
I don’t know the percentage of patients who reported nausea in this study, although they did note that lower doses of naltrexone cause less nausea.
In their previous study, which used 50 mg of naltrexone, 40 percent of patients reported nausea which was due to the naltrexone.
Dropouts: I don’t know how many dropped out due to nausea
I don’t know the percentage of patients who dropped out of this study, however, in their previous study, which used 50 mg of naltrexone, approximately one-out-of-eight patients (12 percent) dropped out of the study due to nausea.
Subjects: 250 patients
This study involved 250 people at 14 sites.
Contrave being developed by Orexigen Therapeutics
Contrave is being developed as a weight loss drug by a company in San Diego, California called Orexigen Therapeutics, the same company that is developing Excalia, which is a combination of Wellbutrin (bupropion) and Zonegran (zonisamide).
OREXIGEN reports positive 24-week results for Contrave phase III obesity treatment study. Press Release, 2006 Sept 26.
Orexigen Therapeutics, Inc.
12481 High Bluff Drive, Suite 160
San Diego, CA 92130
Data on Orexigen’s Clincal Trials
Articles on the same subject can be found here:
On Mar 31, 2007 at 4:55 am Todd wrote:
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I know from my own personal experience that ginger root is effective for topamax induced nausea, I wonder if it'll work for naltrexone nausea as well.
It seems dangerous to take a drug like naltrexone on a chronic basis, what if you're in a car wreck and need morphine?
On Apr 11, 2007 at 8:16 am Larry Hobbs wrote:
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Thanks for the info.
I don't think it would be dangerous because naltrexone wears off pretty quickly.
The worst that would happen is that you might be in pain a little longer before the pain killer started working.
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