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Obese burn less fat during exercise
Thursday, April 26, 2007 12:53 am Email this article
Obese people release less fat from fat cells and burn less fat during exercise than lean people a new paper notes. Quote
Obese people release less fat and burn less fat in response to adrenaline
“Obesity is associated with a blunted beta-adrenoceptor-mediated lipolysis and fat oxidation,” the paper states.
In simple terms this means that obese people release less fat from fat cells (lipolysis), and burn less fat in response to adrenaline and noradrenaline stimulating adrenaline receptors (adrenoceptors).
Among those with this altered gene, women released less fat and burned less fat, men simply released less fat
In this particular study, which looked at obese people with a specific gene which was different than other people—specifically the Arg16 allele of the ADRB2 gene—they found that women with this altered gene, released less fat from fat cells and burned less fat in response to stimulating a specific adrenaline receptor, whereas in men with this altered gene, they released less fat from fat cells, but still burned fat at the same rate as those without this altered gene.
What they must be thinking now
Obese women must be thinking—I’ve been telling my lean friends this for years…
I imagine some obese women who have exercised like crazy over the years trying to get the lose weight are thinking, “I knew it. I’ve told people this for years—that I don’t respond the same way to exercise as lean people—but they wouldn’t believe me.”
Jocken JW, Blaak E, Schiffelers S, Arner P, Van Baak MA, Saris W. Association of a beta-2 adrenoceptor (adrb2) gene variant with a blunted in vivo lipolysis and fat oxidation. Int J Obes (Lond). 2007 May, 31(5):813-19.
AUTHOR’S CONTACT INFORMATION
Dr. J. W. E. Jocken
Department of Human Biology
PO Box 616
6200 MD, Maastricht
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On Apr 27, 2007 at 12:40 am Clabbergirl wrote:
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Absolutely true - naturally thin folks think "walking around the block after dinner" or "pushing away from the table" is all it takes to lose a few pounds, when those of us predisposed to weight gain have been trying to tell them it doesn't work that way for us.
I don't understand the 'response to adrenaline' part of this, however. Forgive my lack of medical knowledge, but this means the subjects were given adrenalin to test lipolysis, not increasing it through exercise?
On Apr 27, 2007 at 12:58 am Larry Hobbs wrote:
. . . . .
During exercise, the body releases adrenaline and noradrenaline which stimulate adrenaline receptors, which forces the body to release fat from fat cells and then burn it.
In this study, they used a drug called isoprenaline, which is an asthma drug that stimulates the same adrenaline receptors, in order to determine how much fat people release and how much was burn.
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