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Overweight bipolar patients lose 8.9 lbs with Meridia, 6.2 lbs with Topamax
Wednesday, June 06, 2007 1:35 am Email this article
Overweight bipolar patients who had gained weight while taking antipsychotic medicine lost an average of 8.9 pounds in six months with Meridia (sibutramine) compared to 6.2 pounds with Topamax (topiramate), however, more than three-fourths of patients dropped out before the end of the study. Dropouts
Dropouts: 78% of Meridia group dropped out, 79% of Topmax group
Seventy-eight percent of patients in the Meridia group and 79 percent of the those in the Topmax group dropped out before the end of the study.
Those in the Topmax group who dropped out tended to do so early in the study, whereas those in the Meridia group dropped out throughout the six months.
Mcelroy S, Frye M, Altshuler L, Suppes T, Hellemann G, Black D, Mintz J, Kupka R, Nolen W, Leverich G, Denicoff K, Post R, Keck PJ. A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders. Bipolar Disord. 2007 Jun, 9(4):426-34.
AUTHOR’S CONTACT INFORMATION
Psychopharmacology Research Program
Department of Psychiatry
University of Cincinnati College of Medicine
Cincinnati, OH, 45267 USA
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