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Meridia plus meal replacement shakes causes weight loss of 23.8 lbs in one year
Wednesday, June 20, 2007 3:26 am Email this article
Meridia (sibutramine) plus two Slim-Fast meal replacement shakes per day caused an average weight loss of 18.3 pounds after three months and 23.8 pounds after one year according to a study from researchers at the University of Kansas School of Medicine in Wichita, Kansas, USA. Subjects
Subjects: 148 obese patients
The study started with 148 obese patients.
First 3 Months
First 3 months: 10 mg of Meridia plus two Slim-Fast meal replacement shakes
For the first three months, all patients were given 10 mg of Meridia (sibutramine) per day plus two Slim-Fast meal replacement shakes and a low-calorie meal for a total of 1200 to 1500 calories per day.
3 Month Weight Loss
Average weight loss of 18.3 lbs in 3 months
The average weight loss during these first three months was 18.3 pounds.
Phase 2: 15 mg Meridia plus one Slim Fast shake or a placebo plus low calorie diet
Patients who lost at least 5 percent of their body weight—113 out of the original 148 patients—were then randomly assigned to receive either 15 mg of Meridia (sibutramine) plus one Slim-Fast meal replacement shake per day plus two low-calorie meals for a total of 1200 to 1500 calories per day or a placebo plus three low-calorie meals per day.
One Year Weight Loss
One year weight loss: 23.8 lbs vs 12.1 lbs
One year after the start of the study—nine months after the start of the second phase—those in the Meridia (sibutramine) group had lost an average total of 23.8 pounds versus 12.1 pounds, a difference of 11.7 pounds.
Conclusion: Meridia plus meal replacement shakes are safe and effective
“Sibutramine plus [low calorie diet] with meal replacements and behavior modification is a safe and effective strategy for achieving and sustaining weight loss in obese patients,” the researchers concluded.
Side effects mild to moderate
Adverse effects were mild to moderate.
Apparently there were some serious adverse effects, however I don’t know what they were because I do not have a copy of this paper yet, but the authors noted that they were not related to the Meridia (sibutramine). However, I would like to know what they were in order to verify this for myself.
Unfortunate that both groups were given meal replacement shakes
Comment: It is unfortunate the placebo group was not put on the same diet as the Meridia group so that we could determine how much of an effect was due to the Meridia (sibutramine) and how much was due to the meal replacement shake.
Meal replacement shakes a good idea with any weight loss program
Meal replacement shakes are a good idea with any diet pill or weight loss program.
Numerous studieshave found that meal replacement shakes work.
Dr. Jay Piatek and Dr. Jerry Darm both told me that meal replacement shakes work.
Here is what Dr. Jay Piateksaid about meal replacement shakes.
Dr. Jay Piatek on Meal Replacement Shakes
Hobbs: What type of meal replacement shakes do you use?
Piatek: High-protein meal replacement shakes from HMR—Health Management Resources. They never cause weight gain. They always cause weight loss. Patients love them. Patients who are stuck on a weight plateau and can’t seem to lose always lose 2 to 5 pounds per week by using the shakes depending on how many they use per day.
Hobbs: How do the HMR shakes compare to SlimFast?
Piatek: They have 70 fewer calories and twice as much protein as SlimFast—15 grams versus 7 grams—and they taste much, much better. I can hardly keep them in stock.
Hobbs: How do patients use them?
Piatek: The easiest way is to have them drink a shake before their main meal of the day to kill their appetite. It reduces their intake by 500 to 800 calories per meal. Another way is to use 3 shakes per day for a week or two—one for breakfast, one for lunch and one before dinner. Some people use this technique one week a month. Using three shakes per day causes a weight loss of 2 or 3 pounds per week.
Another way is to use 5 shakes per day in place of meals for a week or two. This causes a weight loss of about 5 pounds per week. The only time that I allow patients to use them longer than a week or two is diabetics who are taking medicines that are making them fat. I let them use the HMR shakes in stead of eating until the lose 15 or 20 pounds which lets them get off of their diabetes medicine. This is one exception where I do focus on weight in the short-term.
Hobbs: Do people get tired of the taste?
Piatek: No, because we make up recipes with them to vary the taste. They can add orange flavoring or Crystal Lite or soda or fruit to change the flavor.
(Note: Dr. Jerry Darm said the same thing about HMR—‘I’ve looked at the Optifast and Medifast, but I consider HMR’s program to be the best. I think their shakes are the best, and believe me, I’ve tried a lot of different ones.’ HMR can be reached at Health Management Resources, 59 Temple Place, Suite 704, Boston, MA 02111, phone (800) 418-1367 or (617) 357-9876, by fax at (617) 357-9690 or on the web at http://www.hmrprogram.com/.)
Early J, Apovian C, Aronne L, Fernstrom M, Frank A, Greenway F, Heber D, Kushner R, Cwik KM, Walch J, Hewkin A, Blakesley V. Sibutramine plus meal replacement therapy for body weight loss and maintenance in obese patients. Obesity (Silver Spring). 2007 Jun, 15(6):1464-72.
AUTHOR’S CONTACT INFORMATION
Department of Preventive Medicine and Public Health
University of Kansas School of Medicine
1010 N. Kansas Road
Wichita, KS 67214-3199 USA
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