Non-alcoholic fatty liver disease increases risk of hypertension, elevated triglycerides & diabetes

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Friday, July 06, 2007 8:32 am Email this article
Non-alcoholic fatty liver disease increases the risk of hypertension, elevated triglyceride levels, diabetes, pre-diabetes, and elevated cholesterol levels in both obese and non-obese people according to a new study from China. OBESE

 

Hypertension in Obese

Hypertension in obese with fatty livers vs non-fatty livers: 73% vs 57%

High blood pressure was one-fourth again as common in obese people with non-alcoholic fatty liver disease as obese people without non-alcoholic fatty liver disease: 73 percent versus 57 percent.

 

Elevated Triglycerides in Obese

Elevated triglycerides in obese with fatty livers vs non-fatty livers: 39% vs 23%

High triglyceride levels were nearly twice as common in obese people with non-alcoholic fatty liver disease as obese people without non-alcoholic fatty liver disease: 39 percent versus 23 percent.

 

Diabetes in Obese

Diabetes in obese with fatty livers vs non-fatty livers: 23% vs 8%

Diabetes was three times as common in obese people with non-alcoholic fatty liver disease as obese people without non-alcoholic fatty liver disease: 23 percent versus 8 percent.

 

NON-OBESE

This was also true for non-obese people with non-alcoholic fatty liver disease compare to non-obese people without fatty livers.

 

Diabetes in Non-Obese

Diabetes in non-obese with fatty livers vs non-fatty livers: 61% vs 41%

Hypertension was more common: 61 percent versus 41 percent.

 

Elevated Triglycerides in Non-Obese

Elevated Triglycerides in non-obese with fatty livers vs non-fatty livers: 38% vs 15%

High triglyceride levels were more common: 38 percent versus 15 percent.

 

Elevated Cholesterol in Non-Obese

Elevated Cholesterol in non-obese with fatty livers vs non-fatty livers: 30% vs 17%

High cholesterol levels were more common: 30 percent versus 17 percent.

 

Elevated Blood Sugar in Non-Obese

Elevated Blood Sugar in non-obese with fatty livers vs non-fatty livers: 21% vs 10%

Impaired fasting glucose, also referred to as pre-diabetes where fasting blood sugar levels are elevated at 110-125 mg per decileter: 21 percent versus 10 percent.

 

Diabetes in Non-Obese

Diabetes in non-obese with fatty livers vs non-fatty livers: 11% vs 4%

Diabetes was more common: 11 percent versus 4 percent.

 

Subjects

Subjects: 358 patients vs 788 controls

“The study consisted of 358 patients (326 men and 32 women) and 788 matched controls (711 men and 77 women) with a similar [average] age of 39 years and… follow-up of 6 years,” the paper noted.

 

Conclusion

Conclusion: Non-alcoholic fatty liver disease might predict metabolic disorders

“The presence of [non-alcoholic fatty liver disease] might predict the development of metabolic disorders due to insulin resistance, rather than obesity itself,” the authors of the paper concluded.

REFERENCE

Fan J, Li F, Cai X, Peng Y, Ao Q, Gao Y. Effects of nonalcoholic fatty liver disease on the development of metabolic disorders. J Gastroenterol Hepatol. 2007 Jul, 22(7):1086-91.

AUTHOR’S CONTACT INFORMATION

Center for Fatty Liver
Shanghai First People’s Hospital
Jiaotong University
Shanghai, China

Articles on the same subject can be found here:

• Nonalcoholic fatty liver disease