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Symlin (pramlintide) causes weight loss of 8.1 lbs in four months
Wednesday, September 05, 2007 6:17 am Email this article
The diabetes drug Symlin (pramlintide) causes an average weight loss of 8.1 pounds in four months without any changes in lifestyle according to a new study from Dr. Lou Aronne from Cornell University. 5% Weight Loss
One-third lost 5%
Approximately one-third (31 percent) of people given Symlin (pramlintide) lost 5 percent of their body weight.
Side Effects: Nausea most common
The most common side effect was mild nausea which tended to be transient and decrease with continued use.
Subjects: 204 obese people, 80% women
The study involved 204 obese subjects with an average body mass index (BMI) of 37.8 and an average age of 48.
Eighty percent of subjects were women.
Symlin (pramlintide) is a synthetic version of amylin
Symlin (pramlintide) is a synthetic version of a natural hormone called amylin that slows down gastric emptying which decreases food intake.
Maximum dose of 240 mcg
Most (88 percent) of subjects were able to gradually increase their dose to a maximum of 240 micrograms.
The drug was injected under the skin (subcutaneous injection) by subjects before meals.
Additional drug information
Additional information about the drug can be found here.
Aronne L, Fujioka K, Aroda V, Chen K, Halseth A, Kesty NC, Burns C, Lush CW, Weyer C. Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: A phase 2, randomized, placebo-controlled, dose-escalation study. J Clin Endocrinol Metab. 2007 Aug, 92(8):2977-83.
AUTHOR’S CONTACT INFORMATION
Louis J. Aronne, MD
Comprehensive Weight Control Program
Weill Medical College
1165 York Avenue
New York, NY 10021, USA
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