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‘I lost 60 lbs in 10 months on Taranabant’ notes a second subject of Merck’s Phase III trial
Wednesday, October 10, 2007 5:30 am Email this article
Below is a story from a 54-year-old person who lost 60 pounds in 10 months taking Taranabant, a diet drug being developed by Merck. They posted their story in the Discussion Forum, but I wanted to post it here so that more people might see it. This is the second person from the Merck study who has told his story. The first person's story is posted here.
Age and Weight
Age 54, weight 270 lbs
I also have been in the Merck study.
My story is remarkably similar to [John’s, the first subject from the study to tell his story].
I am 54 years old. I started out at 270 lbs.
Lost 60 lbs in 10 months
I lost 60 lbs in 10 months while playing tennis and counting calories (1200 to 1800).
First 10 months
Reduced cravings and appetite for the first 10 months
While on the medication, I would get hungry, but was satisfied with reasonable meals.
For the first time in memory, I stopped obsessing about food.
I don’t know if this makes sense to you, but I stopped craving the good feeling I used to get after eating, a craving that would soon drive me to eat more and more.
I guess it blocks the abnormal level of pleasure I would get from eating, thus decreasing my craving for that level of pleasure.
Risk factors improved
Like you, all my numbers improved as well. [Hobbs: I assume he means blood pressure, cholesterol, etc.]
No side effects and he felt great
I felt great and had zero side effects.
Change after 10 months
Re-randomized after 10 months and the cravings returned
Then at month 10, I was abruptly re-randomized with the reason given, that side effects at the higher doses were of concern.
Well just as you said, it was like a light switch being turned on.
Suddenly cravings returned, satiety decreased and I felt for the first time in 10 months that I was swimming in mud!
Gained, Lost, Gained
Gained, then lost, then gained and is not struggling
Well, I soon gained 15 lbs, then lost 5, then gained another 10.
Now I yo-yo this 5 lbs… and currently I am really struggling.
I hope the drug is approved soon.
I am just eying to hang on until it is available, but I really do have hope now after almost 40 years of constant struggle.
During those 10 months I think I felt like “normal” people feel like.
I was able to plan meals, follow the plan, and it just became a matter of choice, not a struggle of trying to fight compulsions.
Thanks [to John, the first study subject] for sharing your story.
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