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Meridia (sibutramine) causes an average weight loss of 9.2 lbs more than placebo
Friday, November 16, 2007 10:45 am Email this article
Meridia (sibutramine) causes an average weight loss of 9.2 pounds more than placebo or 4.3 percent of body weight more than placebo according to an analysis by researchers from the University of Alberta in Edmonton, Alberta, Canada. Successful Weight Loss and Weight Maintenance
10-30% more maintained weight loss with Meridia than with placebo
Ten to 30 percent more patients given Meridia (sibutramine) than those given placebo maintained most (80-100 percent) of their weight loss.
Increased blood pressure 1.7 mm Hg, diastolic 2.4 mm Hg
Meridia (sibutramine) increased blood pressure by an average of 1.7 mm Hg and diastolic pressure 2.4 mm Hg.
Meridia (sibutramine) increase pulse rate by an average of 4.5 beats per minute.
Side Effects: Insomnia, nausea, dry mouth, and constipation
“Insomnia, nausea, dry mouth, and constipation were more common in patients receiving [Meridia] sibutramine, occurring at frequency rates of 7-20%”, the authors noted.
Subjects: 2,623 people
The analysis included data from 10 studies lasting one to four years which included a total of 2,623 people.
Rucker D, Padwal R, Li SK, Curioni C, Lau DCW. Long term pharmacotherapy for obesity and overweight: Updated meta-analysis. BMJ. published online 2007 Nov 15.
Department of Medicine
University of Alberta
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