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Vitamin D deficiency is associated with metabolic syndrome
Wednesday, February 13, 2008 8:59 am Email this article
"We have shown that vitamin D deficiency is associated with the metabolic syndrome in morbidly obese patients, in relation with a decrease in serum HDL concentrations and an increase in serum triglycerides concentrations," concludes a new study from Spain. "Previous studies have shown this association between vitamin D deficiency and the metabolic syndrome in women and in the general population, and our present findings confirm these results also in morbidly obese people." HDL Levels
HDL levels : 37 vs 45 mg/dl
Levels of HDL cholesterol were lower in those with vitamin D deficiency than those without : 37 versus 44.9 mg per deciliter.
“[V]itamin D appears to be necessary to maintain adequate apolipoprotein A-I concentrations, the main component of HDL cholesterol,” the authors noted.
Triglyceride levels : 163 vs 95 mg/dl
Triglyceride levels were higher in those with vitamin D deficiency than those without : 163 versus 95 mg per deciliter.
Subjects : 73 morbidly obese patients
The study involved 73 consecutive morbidly obese patients with a body mass index ( BMI ) of 40 or more.
63% had metabolic syndrome
Sixty-three ( 63 ) percent had metabolic syndrome.
Vitamin D Deficiency
51% had vitamin D deficiency
Fifty-one ( 51 ) percent had vitamin D deficiency.
Sunlight responsible for 90% of vitamin D in most people
Exposure to sunlight “is responsible for more than 90% of the vitamin D requirement for most people,” the authors note.
Vitamin D deficiency is present in 60-80 percent of morbidly obese patients before weight loss surgery, and 40 percent of the general population according to the authors.
Vitamin D and Insulin
Vitamin D necessary for insulin secretion
“Vitamin D deficiency was linked to impaired insulin secretion” in animals and in humans according to the paper.
Botella-Carretero JI, Alvarez-Blasco F, Villafruela J, Balsa J, Vazquez C, Escobar-Morreale HF. Vitamin d deficiency is associated with the metabolic syndrome in morbid obesity. Clin Nutr. 2007 Oct, 26(5):573-80.
AUTHOR’S CONTACT INFORMATION
Department of Clinical Nutrition
Hospital Ramon y Cajal
28034 Madrid, Spain
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