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Taranabant : 0.5 mg causes average weight loss of 6.4 lbs in 3 months
Monday, March 10, 2008 3:09 pm Email this article
A dose of 0.5 mg of the diet drug taranabant causes an average weight loss of 6.4 pounds in three months compared to 2.6 pounds for those given a placebo according to a new paper. Taranabant is similar to Acomplia ( rimonobant ) in that it is a cannabinoid 1 receptor inverse agonist, but it has not been approved for sale. Subjects
Subjects : 533 people
The study involved 533 patients.
Addy C, Wright H, Laere KV, Gantz I, Erondu N, Musser BJ, Lu K, Yuan J, Sanabria-Bohórquez SM, Stoch A, Stevens C, Fong TM, Lepeleire ID, Cilissen C, Cote J, Rosko K, III ING, Nguyen AM, Gumbiner B, Rothenberg P, Hoon JD, Bormans G, Depré M, Eng W-S, Ravussin E, Klein S, Blundell J, Herman GA, Burns HD, Hargreaves RJ, Wagner J, Gottesdiener K, Amatruda JM, Heymsfield SB. The acyclic cb1r inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. Cell Metab. 2008 Jan, 7(1):1-2.
AUTHOR’S CONTACT INFORMATION
Steven B. Heymsﬁeld, M.D.
Merck Research Laboratories
Rahway, NJ 07065, USA
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