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Taranabant : 4 mg reduces food intake by 1% for one day, 12 mg by 22%
Wednesday, March 12, 2008 7:53 am Email this article
In a one-day, one dose study, 4 mg of taranabant reduced food intake for the day by 1 percent, whereas 12 mg reduced food intake by 22 percent compared to people given a placebo. For comparison, 30 of Meridia ( sibutramine ) reduced food intake by 12 percent. Subjects
Subjects : 36 overweight and obese people
The study involved 36 overweight and moderately obese people.
Each person was given placebo, 4 mg of taranabant, 12 mg of taranabant and 30 mg of Meridia ( sibutramine ) on different occasions so that each person acted as their own control.
These types of study are of limited value
These types of studies—one dose studies—are of limited value because they do not tell us how well a drug works over time.
Addy C, Wright H, Laere KV, Gantz I, Erondu N, Musser BJ, Lu K, Yuan J, Sanabria-Bohórquez SM, Stoch A, Stevens C, Fong TM, Lepeleire ID, Cilissen C, Cote J, Rosko K, III ING, Nguyen AM, Gumbiner B, Rothenberg P, Hoon JD, Bormans G, Depré M, Eng W-S, Ravussin E, Klein S, Blundell J, Herman GA, Burns HD, Hargreaves RJ, Wagner J, Gottesdiener K, Amatruda JM, Heymsfield SB. The acyclic cb1r inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. Cell Metab. 2008 Jan, 7(1):1-2.
AUTHOR’S CONTACT INFORMATION
Steven B. Heymsﬁeld, M.D.
Merck Research Laboratories
Rahway, NJ 07065, USA
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