Pramlintide plus leptin causes weight loss of 12.7% vs 8.4% with pramlintide and 8.2% with leptin

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Monday, June 02, 2008 3:18 pm Email this article
Obese people given two experimental drugs, pramlintide plus leptin, caused an average weight loss of 12.7 percent versus 8.4 percent in those given only pramlintide, and 8.2 percent in those only given leptin according to a study by Amylin Pharmaceuticals in San Diego, California, the company who is developing the drugs. The drugs were injected subcutaneously ( under the skin ) three times a day. The company suggests that pramlintide may help to restore leptin sensitivity which is diminished in obese people. Adverse Effects

Adverse effects : problems at the injection site and nausea

The most common adverse effects were problems at the injection site and nausea, “which were mostly mild to moderate and transient in nature,” according to the paper.

 

Pramlintide

Pramlintide lowers blood sugar

Pramlintide is an amylin analog.

Amylinis a hormone secreted by the pancreas at the same time as insulin and helps with blood sugar control according to Wikipedia.

Pramlintide is a drug that lowers blood sugar.

 

Leptin

Leptin reduces appetite

Leptin is a hormone released by fat cells that reduces appetite.

Leptin was discovered in 1994.

REFERENCE

Roth J, Roland B, Cole R, Trevaskis J, Wey. Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies. Proc Natl Acad Sci U S A. 105(20):7257-62.

AUTHOR’S CONTACT INFORMATION

Jonathan Roth
Amylin Pharmaceuticals, Inc.
San Diego, CA 92121, USA
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Articles on the same subject can be found here:

• Leptin

• Symlin (pramlintide)