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One-fourth of men with lowest adrenaline to mental stress gained 18 lbs more over 18 years
Wednesday, September 29, 2010 11:11 am Email this article
The one-fourth of men who had the lowest release of adrenaline in response to mental stress gained an average of approximately 18 pounds more over an eighteen-year period of time from the time they were 19-years-old until they were 37-years-old according to an interesting study from researchers at Ullevaal University Hospital in Oslo, Norway. Weight Gain
Weight gain : 44 lbs vs 26 lbs
The one-fourth of men with the lowest adrenaline response gained roughly 44 pounds compared to a weight gain of roughly 26 pounds for all the other men, a difference of 18 pounds.
(These numbers are based on my calculations assuming that the average height of the men was 5-foot-10.)
Conclusion : Reduced stimulation of Beta-adrenergic receptors plays a role in development of obesity
“This agrees with the growing amount of evidence indicating that reduced stimulation of beta-adrenergic receptors plays an important role in the development of obesity,” the researchers concluded.
Mice Lacking Beta Adrenergic Receptors
Mice lacking beta adrenergic receptors develop massive obesity
“Mice lacking the beta-1, beta-2, and beta-3-receptors were shown to develop massive obesity on a high-fat diet compared with controls,” the researchers also note.
Comments : This is under-appreciated
Ever since writing my first book 15 years ago, “The New Diet Pills”, the research has suggested to me that small reductions in metabolism and reductions in thermogenesis following a meal were related to weight gain, however, the medical literature has mosty pooh-pooh this idea as if it were nonsense.
This study gives additional evidence that small changes in metabolism have an effect on weight gain.
This is also one of the reasons that I believe that drugs such as ephedrine and caffeine, which increase metabolism for several hours as well as suppress appetite, are the best drugs for helping people lose weight and keep it off.
Comment About Asthma Drugs That Stimulate Metabolism
Comment : I met a guy who was very lean because he was taking 5 asthma medicines
About a dozen years ago I met a guy riding a bike who was extremely lean.
He was wearing a large mask which I asked him about.
He said it was because he had terrible asthma.
I asked if he took drugs for his asthma, and he replied, “Yes, I take 5 different medications every day.”
I thought, “Ah, that’s why he’s so lean.
I also recently was talking to a 20-year-old guy on the basketball court who is very lean and energetic.
He mentioned that he has exercise-induced asthma.
I asked if he takes medication for his asthma.
He said, yes, he takes several medications every day.
Again, I thought, “Ah, that’s why he’s so lean and energetic on the basketball court.”
Comment About Asthma Drugs Used for Asthma, but Not for Obesity
Comment : Medicine has no problem using asthma drugs for asthma, but not for obesity
For some reason, medicine is OK with using asthma drugs for asthma, such as ephedrine and theophylline, but considers them “dangerous” when used for obesity.
This does not make any sense.
Comment About “Ephedrine is Dangerous” Myth
Comment : “Ephedrine is dangerous” myth perpetrated by the drug companies who don’t want competition from ephedrine
I believe the “ephedrine is dangerous” myth was hyped by the drug companies developing obesity drugs because they don’t want the competition from a safe-when-used-as-directed, cheap, effective weight loss drug such as ephedrine.
The drug companies had the FDA do their dirty work and ban ephedra, the herb that contains ephedrine.
It’s a shame.
Flaa A, Sandvik L, Kjeldsen S, Eide I, Rostrup M. Does sympathoadrenal activity predict changes in body fat? An 18-y follow-up study. Am J Clin Nutr. 2008 Jun, 87(6):1596-601.
AUTHOR’S CONTACT INFORMATION
Cardiovascular and Renal Research Center
Department of Acute Medicine
Ullevaal University Hospital, N-0407
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