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    Lifestyle intervention reduced the risk for diabetes to a greater extent than metformin (58% vs 31%)


    Posted by .(JavaScript must be enabled to view this email address)
    Monday, June 23, 2008 2:56 pm Email this article
    "The Diabetes Prevention Program showed that lifestyle intervention reduced the risk for diabetes to a greater extent than the anti-diabetic drug metformin (58% vs. 31%) (Knowler WC et al, 2002)," according to a report titled Australia's future fat bomb that was written by researchers at the Baker IDI Heart and Diabetes Research Institute in Melbourne, Australia.

    The lifestyle-modification program had a goal of losing at least a 7 percent of body weight and at engaging in at least 150 minutes of physical activity per week, while the dose of metformin was 850 mg twice a day.

    Note: The report mistakenly stated that metformin only reduced the risk by 13%, but the number should have been 31%. REFERENCE

    Stewart S, Tikellis G, Carrington M, Walker K, O’dea K. Australia’s future fat bomb : A report on the long-term consequences of australia’s expanding waistline on cardiovascular disease. Baker Heart Research Institute. 2008 Jun 20, http://baker.edu.au/assets/contentFiles/39/fatBomb_report.pdf.

    AUTHOR’S CONTACT INFORMATION

    Professor Simon Stewart
    Head, Preventative Cardiology
    Baker IDI Heart and Diabetes Institute
    PO Box 6492, St Kilda Road Central
    Melbourne Victoria 8008
    Australia
    +61 3 8532 1640 phone
    +61 3 8532 1100 fax
    0438 302 111
    .(JavaScript must be enabled to view this email address)
    http://www.bakeridi.edu.au

    This report is available (pdf file) on request from:
    Dr Gabriella Tikellis: .(JavaScript must be enabled to view this email address)

    OTHER REFERENCES

    Knowler W, Barrett-Connor E, Fowler S, Hamman R, Lachin J, Walker E, Nathan D. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002 Feb 7, 346(6):393-403.

    AUTHOR’S CONTACT INFORMATION

    Diabetes Prevention Program Coordinating Center
    Biostatistics Center
    George Washington University
    6110 Executive Blvd., Suite 750
    Rockville, MD 20852, USA

     

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