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Lifestyle intervention reduced the risk for diabetes to a greater extent than metformin (58% vs 31%)
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Monday, June 23, 2008 2:56 pm Email this article
"The Diabetes Prevention Program showed that lifestyle intervention reduced the risk for diabetes to a greater extent than the anti-diabetic drug metformin (58% vs. 31%) (Knowler WC et al, 2002)," according to a report titled Australia's future fat bomb that was written by researchers at the Baker IDI Heart and Diabetes Research Institute in Melbourne, Australia.
The lifestyle-modification program had a goal of losing at least a 7 percent of body weight and at engaging in at least 150 minutes of physical activity per week, while the dose of metformin was 850 mg twice a day.
Note: The report mistakenly stated that metformin only reduced the risk by 13%, but the number should have been 31%. REFERENCE
Stewart S, Tikellis G, Carrington M, Walker K, O’dea K. Australia’s future fat bomb : A report on the long-term consequences of australia’s expanding waistline on cardiovascular disease. Baker Heart Research Institute. 2008 Jun 20, http://baker.edu.au/assets/contentFiles/39/fatBomb_report.pdf.
AUTHOR’S CONTACT INFORMATION
Professor Simon Stewart
Head, Preventative Cardiology
Baker IDI Heart and Diabetes Institute
PO Box 6492, St Kilda Road Central
Melbourne Victoria 8008
Australia
+61 3 8532 1640 phone
+61 3 8532 1100 fax
0438 302 111
.(JavaScript must be enabled to view this email address)
http://www.bakeridi.edu.au
This report is available (pdf file) on request from:
Dr Gabriella Tikellis: .(JavaScript must be enabled to view this email address)
OTHER REFERENCES
Knowler W, Barrett-Connor E, Fowler S, Hamman R, Lachin J, Walker E, Nathan D. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002 Feb 7, 346(6):393-403.
AUTHOR’S CONTACT INFORMATION
Diabetes Prevention Program Coordinating Center
Biostatistics Center
George Washington University
6110 Executive Blvd., Suite 750
Rockville, MD 20852, USA
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