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    Empatic (Zonegran plus Wellbutrin) caused weight loss of 5-10% in 6 months


    Posted by .(JavaScript must be enabled to view this email address)
    Wednesday, July 16, 2008 6:48 am Email this article
    A drug called Empatic, which is simply a combination of sustained-release Zonegran (zonisamide) plus sustained-release Wellbutrin SR (bupropion), with a minimal amount of diet and exercise caused a weight loss of 5-10 percent after six months for people who completed the study compared to one percent for those given a placebo according to a press release from Orexigen Therapeutics, Inc, the company who is developing the drug. Weight Loss According to Dose

    Weight loss varied from 5-10%

    The most effective dose was 360 mg of sustained-release Zonegran (zonisamide) plus 360 mg of sustained-release Wellbutrin SR (bupropion) which caused an average weight loss of 10.3 percent.

    The lowest doses tested were 120 mg of sustained-release Zonegran (zonisamide) plus 280 mg of sustained-release Wellbutrin SR (bupropion) which caused an average weight loss of 5.3 percent.

    The weight loss according to the various doses were as follows:

    Weight Loss After 6 Months (24 weeks)
    Group
    Zonegran SR
    Wellbutrin SR
    Completers
    Group 1
    120 mg
    280 mg
    5.3%
    Group 2
    120 mg
    360 mg
    7.3%
    Group 3
    240 mg
    280 mg
    7.2%
    Group 4
    240 mg
    360 mg
    7.4%
    Group 5
    360 mg
    280 mg
    8.3%
    Group 6
    360 mg
    360 mg
    10.3%
    Group 7
    Placebo
    Placebo
    1.2%


    Subjects

    Subjects: 623 obese people

    The study involved 623 obese patients with a minimal amount of diet and exercise.

     

    Comments

    Comment: Phentermine plus Zonegran probably better

    Based on what a couple of doctors have told me, Zonegran (zonisamide) plus phentermine is probably a more effective combination than the Zonegran (zonisamide) plus Wellbutrin (bupropion) being used in the drug Empatic. Wellbutrin (bupropion) is simply not very effective at causing weight loss, but phentermine is.

    See the article about how Dr. Jay Piatek uses Zonegran (zonisamide) plus phentermine.

    Articles on the same subject can be found here:


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