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    Empatic (Zonegran plus Wellbutrin) dropouts due to side effects varied from 9-21%


    Posted by .(JavaScript must be enabled to view this email address)
    Wednesday, July 16, 2008 5:11 am Email this article
    A drug called Empatic, which is simply a combination of sustained-release Zonegran (zonisamide) plus sustained-release Wellbutrin SR (bupropion), with a minimal amount of diet and exercise caused a weight loss of 5-10 percent after six months and 11-15 percent after 11 months for people who completed the study compared to one percent for those given a placebo according to a press release from Orexigen Therapeutics, Inc, the company who is developing the drug.

    The number of people who dropped out of the study due to adverse effects varied from 9-21 percent depending on the dose of each drug.

    No one given the highest dose of the drugs dropped out of the study in the last 5 months due to side effects according to a press release from the company.
    Dropouts Due To Adverse Effects

    Dropouts due to side effects varied from 9-21%

    One out of every six patients (16.9 percent) given the highest dose of each drug—360 mg of sustained-release Zonegran (zonisamide) plus 360 mg of sustained-release Wellbutrin SR (bupropion)—dropped out of the study in the first six months due to adverse effects.

     

    No Dropouts Due To Adverse Effects in Last 5 Months

    No one given the highest dose of the drug dropped out due to side effects in the last 5 months

    No one given the highest dose of the drugs dropped out of the study in the last 5 months due to side effects according to a press release from the company.

    The percentage of people who dropped out of the study in the first six months due to side effects according to the various doses were as follows:

         
    Dropouts Due To Adverse Effects Within the First 6 Months
    Group
    Zonegran SR
    Wellbutrin SR
    Dropouts
    Group 1
    120 mg
    280 mg
    10.3%
    Group 2
    120 mg
    360 mg
    9.2%
    Group 3
    240 mg
    280 mg
    10.0%
    Group 4
    240 mg
    360 mg
    20.7%
    Group 5
    360 mg
    280 mg
    16.9%
    Group 6
    360 mg
    360 mg
    16.9%
    Group 7
    Placebo
    Placebo
    9.1%


    Subjects

    Subjects: 623 obese people

    The study involved 623 obese patients with a minimal amount of diet and exercise.

     

    Comments

    Comment: Phentermine plus Zonegran probably better

    Based on what a couple of doctors have told me, Zonegran (zonisamide) plus phentermine is probably a more effective combination than the Zonegran (zonisamide) plus Wellbutrin (bupropion) being used in the drug Empatic. Wellbutrin (bupropion) is simply not very effective at causing weight loss, but phentermine is.

    See the article about how Dr. Jay Piatek uses Zonegran (zonisamide) plus phentermine.

    Articles on the same subject can be found here:


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