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  • CM3 Alginate cellulose fiber capsules do not reduce appetite or delay gastric emptying

    Posted by .(JavaScript must be enabled to view this email address)
    Thursday, August 28, 2008 1:50 pm Email this article
    A product called CM3 Alginate, which is highly cross-linked cellulose, is being sold as a weight loss product. A new study from Germany reveals that it does not work.

    "In obese subjects, acute administration of the weight-loss supplement CM3 does not delay gastric emptying and does not influence subjective appetite sensations." What is CM3?

    CM3 is a highly cross-linked cellulose

    “CM3, a highly cross-linked cellulose in capsule form, expands in the stomach to a size several fold of its original volume,” the paper notes.

    “It is purported to induce a prolonged feeling of satiation and a delay in gastric emptying, thus promoting weight loss.”



    Subjects: 19 obese people

    The study involved “19 moderately obese but otherwise healthy subjects” who, on average, were 55-years-old and had a body mass index (BMI) of 31.



    Dose: 6 capsules 30 minutes before a meal

    Subjects were given either 6 capsules of CM3 or a placebo, 30 minutes before a meal.



    Results: No effect on appetite

    There were no effects on hunger, satiation, fullness, additional food consumption, or desire to eat.


    Comment #1

    Comment: In 1994, I wrote that cellulose does not cause weight loss

    Fourteen years ago, in my first book The New Diet Pills (Pragmatic Press, 1994) I included a chapter on fiber, and wrote that cellulose does not cause weight loss.

    “Cellulose is effective at treating constipation and has the advantage over psyllium of not causing gas. However, cellulose does not cause weight loss, reduce cholesterol, or reduce blood sugar levels. Cellulose is found in the over-the-counter bulk laxative called Citrucel. Cellulose is a water-insoluble fiber found in whole wheat flour, bran, cabbage, peas, beans, apples, and root vegetables. Cellulose is not recommended for losing weight.

    —Larry Hobbs, The New Diet Pills, Pragmatic Press, 1994, Chapter 6, Fiber Supplements, page 82, last paragraph


    Comment #2

    Comment #2: Try glucomannan or guar gum instead

    Don’t waste your money on CM3. It doesn’t work.

    If you want to try a fiber supplement to help you lose weight, try glucomannan or guar gum instead.

    There are studies to back these up. The weight loss is not enormous, but they tend to help when a person is dieting.


    Heiner K. Berthold SU, Ralf Degenhardt, Martin Unverdorben And Ioanna Gouni-Berthold. Effect of a cellulose-containing weight-loss supplement on gastric emptying and sensory functions. Obesity (Silver Spring). 2008 July 24, 16(8):published early on-line.


    Heiner K. Berthold
    Department of Clinical Pharmacology
    Institute for Clinical Research
    Center for Cardiovascular Diseases
    Rotenburg an der Fulda, Germany
    .(JavaScript must be enabled to view this email address)


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